1211527-07-9

Usage

Uses

Used in Pharmaceutical Development:
7-bromobenzo[d]oxazol-2-amine is used as a building block in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs and therapeutic agents. Its unique structure and properties allow it to be incorporated into various drug molecules, enhancing their efficacy and selectivity.
Used in Agrochemical Development:
7-bromobenzo[d]oxazol-2-amine is used as a key intermediate in the synthesis of agrochemicals, particularly in the development of new pesticides and herbicides. Its biological activities and pharmacological properties make it a valuable component in the design and synthesis of effective and targeted agrochemicals.
Used in Organic Synthesis:
7-bromobenzo[d]oxazol-2-amine is used as a versatile reagent in organic synthesis, enabling the formation of a wide range of chemical compounds. Its reactivity and functional groups make it suitable for various synthetic transformations, facilitating the creation of diverse chemical libraries.
Used in Medicinal Chemistry Research:
7-bromobenzo[d]oxazol-2-amine is used as a research tool in medicinal chemistry, aiding scientists in understanding the structure-activity relationships of various biologically active compounds. Its unique structure and properties provide insights into the design and optimization of drug candidates, contributing to the advancement of drug discovery efforts.

Upstream product

• 506-68-3 bromocyane 
• 28165-50-6 2-amino-6-bromophenol 
• 1013642-98-2 7-bromo-2-(methylthio)benzo[d]oxazole 
• 1013643-09-8 7-bromobenzo[d]oxazole-2-thiol 
• 13073-25-1 2-bromo-6-nitro-phenol 

Downstream Products

• 1580483-38-0 C₁₄H₁₁FN₂O₂ 
• 2056915-53-6 2-aminobenzo[d]oxazol-7-ylboronic acid 

Relevant academic research and scientific papers

Chemical synthesis and molecular modeling of novel substituted N-1,3-benzoxazol-2yl benzene sulfonamides as inhibitors of inhA enzyme and Mycobacterium tuberculosis growth

Abstract: Tuberculosis (TB) is one of the major contagious diseases with high mortality which is caused by Mycobacterium tuberculosis (Mtb) pathogen. Due to the existing antibiotic resistance (MDR-TB) to tuberculosis, the demand for the development of new potential chemotherapy drugs is increasing. Herein, we report synthesis of two novel benzoxazole-based series, namely 2-phenyl benzoxazole sulfonamide and 2-piperidine-benzoxazole sulfonamides. These compounds were evaluated for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv strain, using the microplate alamarBlue assay. Molecular docking studies were carried out to comprehend the binding mode of the compounds. It is evident from molecular docking studies and minimum inhibitory concentration assay (MIC) that 2-phenyl benzoxazole sulfonamide scaffold has a greater potential of antitubercular activity possibly by ENR inhibition (inhA inhibitors). In silico cytotoxicity studies using CLC-Pred tool database suggested that both the series were relatively safe. Graphic abstract: [Figure not available: see fulltext.].

METALLO-BETA-LACTAMASE INHIBITORS

The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors

2-Amino-7-substituted benzoxazole analogs were identified by HTS as inhibitors of RSK2. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus of improving in vitro and target modulation potency and physicochemical properties.