1211541-09-1

Basic information

• Product Name: 3-Bromo-5-(2-thienyl)pyridine
• Synonyms: 3-Bromo-5-(2-thienyl)pyridine
• CAS NO: 1211541-09-1
• Molecular Formula: C9H6BrNS
• Molecular Weight: 240
• Mol File: 1211541-09-1.mol

Chemical Properties

• Boiling Point: 306℃
• Flash Point: 139℃
• Appearance: /
• Density: 1.563
• CAS DataBase Reference: 3-Bromo-5-(2-thienyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-5-(2-thienyl)pyridine(1211541-09-1)
• EPA Substance Registry System: 3-Bromo-5-(2-thienyl)pyridine(1211541-09-1)

Safety Data

• Hazardous Substances Data: 1211541-09-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Bromo-5-(2-thienyl)pyridine is utilized as a key intermediate in the synthesis of pharmaceuticals for its ability to form complex molecular structures with specific therapeutic properties. Its reactivity allows for the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Bromo-5-(2-thienyl)pyridine is employed as a building block for the creation of novel agrochemicals, contributing to the development of more effective and targeted pesticides and other agricultural products.
Used in Material Science:
3-Bromo-5-(2-thienyl)pyridine is used as a versatile intermediate in material science for the design and synthesis of new materials with unique properties. Its incorporation into material compositions can lead to advancements in areas such as electronics, optoelectronics, and nanotechnology.
Used in Research and Development:
3-Bromo-5-(2-thienyl)pyridine serves as a valuable compound in research and development settings, where its unique structure and reactivity are harnessed to explore new chemical reactions and syntheses, potentially leading to breakthroughs in various scientific and industrial applications.

Upstream product

• 1003-09-4 2-bromothiophene 
• 452972-09-7 (5-bromopyridin-3-yl)boronic acid 
• 3437-95-4 2-Iodothiophene 
• 625-92-3 3,5-dibromopyridine 
• 6165-68-0 thiophene boronic acid 

Relevant articles and documents

Design and synthesis of thienylpyridyl garlands as non-peptidic alpha helix mimetics and potential protein-protein interactions disruptors

This paper describes an efficient route leading to new thienylpyridyl garlands as non-peptidic alpha helix mimetics and potential protein-protein interactions disruptors. Firstly, we have studied the reactivity of boronic acids and halogenated pyridines and/or thiophenes towards the Suzuki-Miyaura cross-coupling reaction in order to obtain bis-thienylpyridines. Secondly, we have functionalized these compounds by a reaction of bromination and the resultant bis-bromothienylpyridines have been found to undergo iterative Pd-catalyzed coupling based on a pseudo-Garlanding approach with a range of pyridyl boronic acids to produce a new library of thienylpyridyl oligomers.

NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF

An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. Th e present invention provides a nicotinamide derivative represented by the follo wing formula (I) (wherein R 1 represents a halogen atom; R 2 represents a C 1-12 alkyl group, a C 2-12 alkenyl group, a C 2-12 alkynyl group, a C 3-8 cycloalkyl g roup, an aryl group, an ar-C 1-6 alkyl group or a heterocyclic group, each opti onally having at least one substituent; R 3 represents an aryl group or a hetero cyclic group each optionally having at least one substituent; and R 4 and R 5 e ach independently represent a hydrogen atom; and R 2 and R 4 may form a cyc lic amino group optionally having at least one substituent together with the ni trogen atom to which they bind) or a salt thereof, and a pharmaceutical comp osition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.