1211548-00-3Relevant academic research and scientific papers
Four-component synthesis of fully substituted 1,2,4-triazoles
Staben, Steven T.,Blaquiere, Nicole
, p. 325 - 328 (2010)
Chemical Equation Presented All 4 one: Palladium-catalyzed carbonylation initiates a highly regioselective triazole synthesis. In this four-partner protocol, the aryl halide, amidine, and hydrazine partners are easily varied, allowing the synthesis of fully substituted 1,2,4-triazoles in a modular fashion. This methodology is demonstrated with the synthesis of druglike and/or pharmaceutically relevant molecules such as deferasirox.
