1211596-75-6 Usage
General Description
Methyl 2-Cyano-3-(Trifluoromethyl)Benzoate is a compound with the chemical formula C10H6F3NO2. It is a pale yellow liquid with a molecular weight of 229.15 g/mol. This chemical is widely used in the pharmaceutical and agrochemical industries as an intermediate for the synthesis of various compounds. It is also known for its insecticidal and fungicidal properties. Methyl 2-Cyano-3-(Trifluoromethyl)Benzoate is a versatile building block in organic synthesis and has applications in the production of pharmaceuticals and crop protection products. Its unique chemical structure makes it valuable for the development of new drugs and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 1211596-75-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,1,5,9 and 6 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1211596-75:
(9*1)+(8*2)+(7*1)+(6*1)+(5*5)+(4*9)+(3*6)+(2*7)+(1*5)=136
136 % 10 = 6
So 1211596-75-6 is a valid CAS Registry Number.
1211596-75-6Relevant articles and documents
Discovery of Orally Bioavailable Ligand Efficient Quinazolindiones as Potent and Selective Tankyrases Inhibitors
Qin, Donghui,Lin, Xiaojuan,Liu, Zhi,Chen, Yan,Zhang, Zhiliu,Wu, Chengde,Liu, Linlin,Pan, Yan,Laquerre, Sylvie,Emery, John,Fergusson, Jeff,Roland, Kimberly,Keenan, Rick,Oliff, Allen,Kumar, Sanjay,Cheung, Mui,Su, Dai-Shi
supporting information, p. 1005 - 1010 (2021/05/27)
We report herein the discovery of quinazolindiones as potent and selective tankyrase inhibitors. Elucidation of the structure-activity relationship of the lead compound 1g led to truncated analogues that have good potency in cells, pharmacokinetic (PK) properties, and excellent selectivity. Compound 21 exhibited excellent potencies in cells and proliferation studies, good selectivity, in vitro activities, and an excellent PK profile. Compound 21 also inhibited H292 xenograft tumor growth in nude mice. The synthesis, biological, pharmacokinetic, in vivo efficacy studies, and safety profiles of compounds are presented.
