178748-05-5

Basic information

• Product Name: 2-FLUORO-3-(TRIFLUOROMETHYL)PHENYLACETIC ACID
• Synonyms: 2-FLUORO-3-(TRIFLUOROMETHYL)PHENYLACETIC ACID;RARECHEM AL BO 0627;2-(2-fluoro-3-(trifluoromethyl)phenyl)acetic acid;2-fluoro-3-trifluoroethylphenylacetic acid;2-Fluoro-3-(trifluoromethyl)benzoic acid methyl ester;Benzoic acid, 2-fluoro-3-(trifluoroMethyl)-, Methyl ester
• CAS NO: 178748-05-5
• Molecular Formula: C9H6F4O2
• Molecular Weight: 222.14
• EINECS: 200-258-5
• Product Categories: Fluorine series
• Mol File: 178748-05-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 113-116 °C(lit.)
• Boiling Point: 228℃
• Flash Point: 89℃
• Appearance: /
• Density: 1.345
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-FLUORO-3-(TRIFLUOROMETHYL)PHENYLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-3-(TRIFLUOROMETHYL)PHENYLACETIC ACID(178748-05-5)
• EPA Substance Registry System: 2-FLUORO-3-(TRIFLUOROMETHYL)PHENYLACETIC ACID(178748-05-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 178748-05-5(Hazardous Substances Data)

Usage

General Description

2-Fluoro-3-(Trifluoromethyl)phenylacetic acid is a synthetic, organic compound that belongs to the class of organic compounds known as trifluoromethylbenzenes. These are organofluorine compounds that contain a benzene substituted by one or more trifluoromethyl groups. It's also known as α,α,α-trifluoro-m-tolylacetic acid. The chemical is relatively stable and is used in various applications in the field of organic synthesis and pharmaceutical manufacturing. The compound is typically prepared through a process involving the use of trifluoromethyl reagents, and it is characterized by its strong acidity due to the electron-withdrawing effect of the trifluoromethyl groups.

Upstream product

• 115029-22-6 2-fluoro-3-(trifluoromethyl)benzoic acid 
• 392-85-8 1-fluoro-2-trifluoromethylbenzene 
• 67-56-1 methanol 

Downstream Products

• 1211596-75-6 methyl 2-cyano-3-(trifluoromethyl)benzoate 

Relevant articles and documents

Discovery of Orally Bioavailable Ligand Efficient Quinazolindiones as Potent and Selective Tankyrases Inhibitors

We report herein the discovery of quinazolindiones as potent and selective tankyrase inhibitors. Elucidation of the structure-activity relationship of the lead compound 1g led to truncated analogues that have good potency in cells, pharmacokinetic (PK) properties, and excellent selectivity. Compound 21 exhibited excellent potencies in cells and proliferation studies, good selectivity, in vitro activities, and an excellent PK profile. Compound 21 also inhibited H292 xenograft tumor growth in nude mice. The synthesis, biological, pharmacokinetic, in vivo efficacy studies, and safety profiles of compounds are presented.

QUINAZOLINEDIONES AS TANKYRASE INHIBITORS

This invention relates to the use of quinazolinediones for the modulation, notably the inhibition of the activity of tankyrases (TNKS1 and TNKS2). Suitably, the present invention relates to the use of quinazolinediones in the treatment of cancer, fibrosis and other hyperproliferative diseases through this mechanism.