121177-67-1

Basic information

• Product Name: 5-IODO-2,4-DIMETHOXY-BENZALDEHYDE
• Synonyms: 5-IODO-2,4-DIMETHOXY-BENZALDEHYDE;5-Iodo-2,4-dimethoxybenzaldehyde 97%
• CAS NO: 121177-67-1
• Molecular Formula: C₉H₉IO₃
• Molecular Weight: 292.07
• Mol File: 121177-67-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 172-176°C
• Appearance: /
• CAS DataBase Reference: 5-IODO-2,4-DIMETHOXY-BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-IODO-2,4-DIMETHOXY-BENZALDEHYDE(121177-67-1)
• EPA Substance Registry System: 5-IODO-2,4-DIMETHOXY-BENZALDEHYDE(121177-67-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38-43-52
• Safety Statements: 26-36/37
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 121177-67-1(Hazardous Substances Data)

Usage

General Description

5-IODO-2,4-DIMETHOXY-BENZALDEHYDE is a chemical compound with the molecular formula C9H9IO3. It is an organic compound with a benzene ring substituted with two methoxy groups and an aldehyde functional group, as well as an iodine atom. 5-IODO-2,4-DIMETHOXY-BENZALDEHYDE is commonly used in the synthesis of various pharmaceuticals and organic compounds due to its versatile reactivity and functional groups. It is also known for its use in organic chemistry research and as a reagent in chemical reactions. Additionally, 5-IODO-2,4-DIMETHOXY-BENZALDEHYDE has shown potential antimicrobial and anticancer properties in some studies, making it a subject of interest in medicinal and biological research.

Upstream product

• 552845-97-3 2,4-dimethoxy-5-thiazol-2-yl-benzaldehyde 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 552845-84-8 2-(5-bromo-2,4-dimethoxy-phenyl)-[1,3]dioxolane 
• 930601-46-0 2-(5-[1,3]dioxolan-2-yl-2,4-dimethoxy-phenyl)-thiazole 
• 130333-46-9 5-bromo-2, 4-dimethoxybenzaldehyde 

Downstream Products

• 809240-72-0 5-(2-aminophenylethynyl)-2,4-dimethoxybenzaldehyde 
• 1009736-88-2 tert-butyl ((S)-1-(((2S,3S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-(5-((Z)-2-iodovinyl)-2,4-dimethoxyphenyl)-1-oxopropan-2-yl)(methyl)carbamate 
• 1416500-56-5 2,4-dimethoxy-5-((trimethylsilyl)ethynyl)benzaldehyde 
• 552846-02-3 5-(1H-indol-2-yl)-2,4-dimethoxybenzaldehyde 
• 930601-47-1 N-[2-(5-formyl-2,4-dimethoxyphenylethynyl)phenyl]-2,2-dimethylpropionamide 

Relevant articles and documents

Comparison of iodination of methoxylated benzaldehydes and related compounds using iodine/silver nitrate and iodine/periodic acid

Iodination of the three methoxybenzaldehydes, four dimethoxybenzaldehydes, vanillin, and piperonal by two methods were compared. Iodine and periodic acid gave better yields for iodination for the methoxybenzaldehydes, whereas iodine and silver nitrate generally gave better yields for the rest of the compounds. Copyright Taylor & Francis Group, LLC.

C-H Functionalization of N-Methylated Amino Acids and Peptides as Tool in Natural Product Synthesis: Synthesis of Abyssenine A and Mucronine e

N-Methylated amino acids and peptides with an 8-aminoquinoline (AQ) directing group can be subjected to stereoselective Pd-catalyzed β-functionalizations. The best results are obtained with aryl iodides, but alkyl and alkenyl side chains can also be introduced. The AQ protecting group can easily be removed, providing the free carboxylic acid, which can be used directly in peptide couplings. This protocol was used successfully as a key step in the synthesis of the cyclopeptide alkaloids abyssenine A and mucronine E.

Highly Regioselective Iodination of Arenes via Iron(III)-Catalyzed Activation of N-Iodosuccinimide

An iron(III)-catalyzed method for the rapid and highly regioselective iodination of arenes has been developed. Use of the powerful Lewis acid, iron(III) triflimide, generated in situ from iron(III) chloride and a readily available triflimide-based ionic liquid allowed activation of N-iodosuccinimide (NIS) and efficient iodination under mild conditions of a wide range of substrates including biologically active compounds and molecular imaging agents.