121180-58-3Relevant academic research and scientific papers
Exploring the scope for scale-up of organic chemistry using a large batch microwave reactor
Schmink, Jason R.,Kormos, Chad M.,Devine, William G.,Leadbeater, Nicholas E.
experimental part, p. 205 - 214 (2010/04/29)
A new batch microwave reactor has been evaluated in the context of palladium-mediated transformations, condensation reactions, nucleophilic aromatic substitution reactions, and alkylations. Importantly, a linear scaling approach was taken, no changes being made to the protocol when moving from the small, developmental scale to larger scales. In some cases reactions were scaled over 18,000-fold when moving from small (0.1-1 mmol) to large (1-18 mol) runs.
Synthesis and antimicobacterial activity of 2-substituted 4-arylamino-6-methylpyrimidines
Erkin,Krutikov,Smirnova
experimental part, p. 1944 - 1948 (2009/02/08)
2-Substituted 4-arylamino-6-methylpyrimidines were synthesized by stepwise modification of the structure of 6-methyl-2-thiouracyl through the intermediate 2-(ar)alkylthio-6-methyl-4-chloropyrimidines. Some of the compounds synthesized exhibit expressed antimycobacterial activity.
