3019-17-8

Basic information

• Product Name: 4(1H)-Pyrimidinone, 6-methyl-2-[(phenylmethyl)thio]-
• Synonyms: 4(1H)-Pyrimidinone, 6-methyl-2-[(phenylmethyl)thio]-;2-(benzylthio)-6-methylpyrimidin-4(3H)-one;2-(benzylsulfanyl)-6-methyl-4-pyrimidinol
• CAS NO: 3019-17-8
• Molecular Formula: C₁₂H₁₂N₂OS
• Molecular Weight: 232.30148
• Mol File: 3019-17-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 176-178 °C
• Boiling Point: 374.6±35.0 °C(Predicted)
• Appearance: /
• Density: 1.22±0.1 g/cm3(Predicted)
• PKA: 8.07±0.50(Predicted)
• CAS DataBase Reference: 4(1H)-Pyrimidinone, 6-methyl-2-[(phenylmethyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pyrimidinone, 6-methyl-2-[(phenylmethyl)thio]-(3019-17-8)
• EPA Substance Registry System: 4(1H)-Pyrimidinone, 6-methyl-2-[(phenylmethyl)thio]-(3019-17-8)

Safety Data

• Hazardous Substances Data: 3019-17-8(Hazardous Substances Data)

Upstream product

• 56-04-2 6-methyl-2-thiouracil 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 538-28-3 S-benzylisothiourea hydrochloride 
• 141-97-9 ethyl acetoacetate 
• 56-04-2 6-methyl-2-thiouracil 
• 56-04-2 2-mercapto-6-methylpyrimidin-4(3H)-one 
• 22874-42-6 4-hydroxy-2-mercapto-6-methylpyrimidine S-sodium salt 

Downstream Products

• 115996-86-6 (2-Benzylsulfanyl-6-methyl-pyrimidin-4-yloxy)-acetic acid methyl ester 
• 1130279-69-4 2-(benzylsulfanyl)-4-(difluoromethoxy)-6-methylpyrimidine 
• 105114-05-4 2-benzylthio-4-hydroxy-6-methylpyrimidine O-sodium salt 
• 1207188-10-0 (S)-methyl 3-(2-(benzylsulfanyl)-6-methylpyrimidin-4-yloxy)-2-(tritylamino)propanoate 
• 121180-58-3 2-(benzylthio)-4-chloro-6-methylpyrimidine 
• 1035913-14-4 tert-butyl (S)-2-(2-(benzylsulfanyl)-6-methylpyrimidin-4-yloxy)-3-methylbutan-2-ylcarbamate 
• 1035913-24-6 tert-butyl (S)-2-((2-(benzylsulfanyl)-6-methylpyrimidin-4-yloxy)-methyl)pyrrolidine-1-carboxylate 

Relevant articles and documents

Features of the synthesis of S-monobenzyl and S,O-dibenzyl, di(m-phenoxybenzyl) derivatives of 6-methyl-2-thiouracil

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Studies on solubility and S-alkylation of 2-thiouracil in ionic liquids

Ionic liquids have been exploited to assist dissolution of poorly soluble (and poorly bioavailable) drugs, enhancing permeation through physiological barriers to deliver drugs to target sites. Herein, the solubility of 6-methyl-2-thiouracil – a common ant

HEPATITIS B VIRAL ASSEMBLY EFFECTORS

Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.