1211884-51-3

Basic information

• Product Name: 4-(6-hydroxy-4-isopropyl-7-oxo-1,3,5-cycloheptatrienylmethyl)-1-(4-nitrobenzyl)piperazine
• CAS NO: 1211884-51-3
• Molecular Weight: 397.474
• Mol File: 1211884-51-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(6-hydroxy-4-isopropyl-7-oxo-1,3,5-cycloheptatrienylmethyl)-1-(4-nitrobenzyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(6-hydroxy-4-isopropyl-7-oxo-1,3,5-cycloheptatrienylmethyl)-1-(4-nitrobenzyl)piperazine(1211884-51-3)
• EPA Substance Registry System: 4-(6-hydroxy-4-isopropyl-7-oxo-1,3,5-cycloheptatrienylmethyl)-1-(4-nitrobenzyl)piperazine(1211884-51-3)

Safety Data

• Hazardous Substances Data: 1211884-51-3(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 499-44-5 hinokitiol 
• 58198-49-5 1-(4-nitrobenzyl)piperazine 

Relevant articles and documents

Synthesis of tropolone derivatives and evaluation of their in vitro neuroprotective activity

β-Thujaplicin (hinokitiol or 2-hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one), a natural tropolone, shows numerous activities while its synthetic analogues were found to exhibit anticancer and anti-ischemic activity. However, the ability of tropolone derivatives to protect neuronal cells from oxidative stress-induced cell damage has not been studied so far. As an ongoing effort toward highly effective antioxidants with potential neuroprotective activity, we have synthesized 7-substituted derivatives of β-thujaplicin and its methoxy analogue. The substituents were heterocycles (piperazine, morpholine) or heteroaromatics (triazoles, pyridine). Only the piperazine derivatives of β-thujaplicin were able to protect HT22 hippocampal neurons from oxidative stress-induced cell death.