58198-49-5

Basic information

• Product Name: 1-(4-Nitrobenzyl)PiperazineHydrochloride
• Synonyms: Piperazine, N-(p-nitrobenzyl)-, hydrochloride;Usaf in-821;1-(4-nitrobenzyl)piperazine(SALTDATA: HCl);4-(Piperazin-1-ylmethyl)nitrobenzene;4-amino-N-(3-morpholin-4-ylpropyl)-1,2,5-oxadiazole-3-carboxamide;1-(4-Nitrobenzyl)PiperazineHydrochloride;4-nitrobenzylpiperazine;1-[(4-Nitrophenyl)methyl]piperazine
• CAS NO: 58198-49-5
• Molecular Formula: C₁₁H₁₅N₃O₂
• Molecular Weight: 221.26
• Mol File: 58198-49-5.mol
• Article Data: 20

Chemical Properties

• Melting Point: 122-123 °C
• Boiling Point: 365.8°Cat760mmHg
• Flash Point: 175.1°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 1.53E-05mmHg at 25°C
• Refractive Index: 1.579
• PKA: 9.03±0.10(Predicted)
• CAS DataBase Reference: 1-(4-Nitrobenzyl)PiperazineHydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Nitrobenzyl)PiperazineHydrochloride(58198-49-5)
• EPA Substance Registry System: 1-(4-Nitrobenzyl)PiperazineHydrochloride(58198-49-5)

Safety Data

• Hazardous Substances Data: 58198-49-5(Hazardous Substances Data)

Usage

General Description

1-(4-Nitrobenzyl)piperazine hydrochloride is a chemical compound that consists of a piperazine ring with a 4-nitrobenzyl group attached to it, and a hydrochloride salt. 1-(4-Nitrobenzyl)PiperazineHydrochloride is used in research and pharmaceutical applications as a precursor for the synthesis of various organic compounds and pharmaceutical drugs. It acts as a reagent for the preparation of a variety of substituted piperazines, which have potential biological activity, including as dopamine receptor ligands and antihistamines. The hydrochloride salt form of this compound is water-soluble and stable, making it suitable for use in various laboratory and industrial processes. The 4-nitrobenzyl group attached to the piperazine ring is important for its reactivity and stability, enabling it to be used as a versatile building block in organic synthesis.

InChI:InChI=1/C11H15N3O2/c15-14(16)11-3-1-10(2-4-11)9-13-7-5-12-6-8-13/h1-4,12H,5-9H2

Upstream product

• 110-85-0 piperazine 
• 555-16-8 4-nitrobenzaldehdye 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 100-14-1 4-nitrobenzyl chloride 
• 130636-61-2 1-[(4-nitrophenyl)methyl]-4-tert-butyloxycarbonylpiperazine 
• 619-73-8 4-nitrobenzyl chloride 
• 142-64-3 piperazine dihydrochloride 

Downstream Products

• 130636-61-2 1-[(4-nitrophenyl)methyl]-4-tert-butyloxycarbonylpiperazine 
• 850171-04-9 2-bromo-4-(4-methanesulfonylpiperazin-1-ylmethyl)aniline 
• 850171-46-9 trans-3-{2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]vinyl}quinoline 
• 863969-66-8 2-[5-(4-methanesulfonyl-piperazin-1-ylmethyl)-2-nitro-phenyl]-1-quinolin-3-yl-ethanol 
• 820976-77-0 trans-3-{2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]vinyl}-2-methoxyquinoline 
• 850171-48-1 trans-3-{2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]vinyl}-2-chloroquinoline 
• 850171-14-1 2-[5-(4-methanesulfonylpiperazin-1-ylmethyl)-2-nitrophenyl]-1-(2-chloroquinolin-3-yl)ethanol 
• 850171-27-6 1-(2-chloroquinolin-3-yl)-2-(5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-2-nitrophenyl)ethanone 
• 615552-65-3 1-(methylsulfonyl)-4-{4-nitro-3-[(trimethylsilyl)methyl]benzyl}piperazine 
• 328058-21-5 4-(4-(methanesulfonyl)piperazin-1-yl-methyl)aniline 
• 796854-51-8 2-[5-(4-methanesulfonyl-piperazin-1-yl-methyl)-2-nitrophenyl]-1-(2-methoxyquinolin-3-yl)-ethanol 
• 304897-49-2 4-(4-tert-butoxycarbonyl-piperazino-methyl)-aniline 
• 1146971-39-2 C₂₆H₃₆N₄O₅ 
• 1211884-51-3 4-(6-hydroxy-4-isopropyl-7-oxo-1,3,5-cycloheptatrienylmethyl)-1-(4-nitrobenzyl)piperazine 

Relevant articles and documents

Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors

Starting from the molecular simplification of (R) 4-(3,4-dibenzylpiperazine-1-carbonyl)benzenesulfonamide 9a, a compound endowed with selectivity for human Carbonic Anhydrase (hCA) IV, a series of piperazines and 4-aminopiperidines carrying a 4-sulfamoylb

The synthesis and biological evaluation of novel gardenamide A derivatives as multifunctional neuroprotective agents

A novel series of gardenamide A derivatives was synthesized as potential anti-Alzheimer's disease agents. The neuroprotective effects of these multifunctional agents against oxygen-glucose deprivation (OGD)-induced neurotoxicity in rat cortical neurons, and hydrogen peroxide (H2O2)- A nd amyloid-β1-42 (Aβ1-42)-induced neurotoxicity in rat hippocampal neurons were evaluated. In vitro studies revealed that these compounds demonstrated moderate to good multifunctional neuroprotective activity. Among the entire series, compounds 10e, 10j, 10n and 10p appeared to be the most active multifunctional neuroprotective agents. Studies indicate that compounds 10e, 10f, 10h, 10i, 10j, 10n and 10p exhibit significant activities against OGD-induced neurotoxicity in rat cortical neurons, and 10e, 10j, 10n and 10p show prominent activities against H2O2- A nd Aβ1-42-induced neurotoxicity in rat hippocampal neurons. Moreover, these derivatives did not exert conspicuous neurotoxicity in rat cortical neurons. Thus, the present study evidently shows that 10e, 10j, 10n and 10p are potent multifunctional neuroprotective agents, which may serve as promising lead candidates for anti-Alzheimer's disease drug development.

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