1211936-72-9

Upstream product

• 86-93-1 1-Phenyl-1H-tetrazole-5-thiol 
• 309241-45-0 4-(1-phenyl-1H-tetrazole-5-sulfonyl)-butyraldehyde 
• 1211936-70-7 C₁₇H₂₈N₄OSSi 

Downstream Products

• 1211936-73-0 5-((4-((tert-butyldimethylsilyl)oxy)butyl)sulfonyl)-1-phenyl-1H-tetrazole 
• 309241-45-0 4-(1-phenyl-1H-tetrazole-5-sulfonyl)-butyraldehyde 

Relevant academic research and scientific papers

Chemoselective reduction of aldehydes: Via a combination of NaBH4 and acetylacetone

A bench-stable combination of NaBH4-acetylacetone was developed for the efficient chemoselective reduction of aldehydes in the presence of ketones. This method offers a useful synthetic protocol for distinguishing carbonyl reaction sites, and its synthetic utility is reflected by its moisture tolerance and high efficiency in a variety of complex settings.

Stereoselective organocatalytic oxidation of alcohols to enals: A homologation method to prepare polyenes

A novel method for organocatalytic oxidation through oxidative enamine catalysis was developed with excellent compatibility for the direct syntheses of enals from simple saturated alcohols. By using this amine-catalyzed IBX-oxidation, a wide range of aromatic and aliphatic substituted enals were successfully generated in high yields and exclusively stereoselective E-geometry. Moreover, varying the solvents and/or the loading amounts of IBX allowed for the selective oxidation of alcohols and aldehydes. Importantly, the homologous application of this method provided a selective and efficient way of preparing various highly sensitive conjugated polyene frameworks, which are enriched in natural products.

Combined rhodium-catalyzed carbon-hydrogen activation and β-carbon elimination to access eight-membered rings

(Figure Presented) Enlargel C-H bond activation and β-carbon elimination are combined in a net intramolecular hydroacylation of alkylidenecyclobutanes and alkylideneazetidines in the presence of rhodium catalysts, affording eight-membered-ring compounds in high yield (see scheme). This study demonstrates the possibility of exploiting the strain energy of azetidines through β-carbon elimination in new transition-metal-catalyzed reactions.