309241-45-0

Upstream product

• 1211936-70-7 C₁₇H₂₈N₄OSSi 
• 1211936-72-9 4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)butan-1-ol 
• 381673-09-2 4-(1-phenyl-1H-tetrazole-5-ylthio)butanenitrile 
• 86-93-1 1-Phenyl-1H-tetrazole-5-thiol 
• 309241-44-9 4-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]butanenitrile 

Downstream Products

• 1211936-72-9 4-((1-phenyl-1H-tetrazol-5-yl)sulfonyl)butan-1-ol 
• 5378-52-9 phenyl-1H-tetrazole 

Relevant academic research and scientific papers

Stereoselective synthesis of C17-C34 fragment of antascomicin A

This Letter describes the synthesis of C17-C34 unit of antascomicin A. A diastereoselective radical cyclization strategy has been developed to construct the highly substituted cyclohexane ring with required stereochemistry present in the molecule. Other key features in the synthesis are Sharpless asymmetric epoxidation, substrate controlled regioselective epoxide opening reaction with Gilman's reagent, dithiane mediated CC bond formation reaction, and modified Julia olefination reaction.

Chemoselective reduction of aldehydes: Via a combination of NaBH4 and acetylacetone

A bench-stable combination of NaBH4-acetylacetone was developed for the efficient chemoselective reduction of aldehydes in the presence of ketones. This method offers a useful synthetic protocol for distinguishing carbonyl reaction sites, and its synthetic utility is reflected by its moisture tolerance and high efficiency in a variety of complex settings.

Towards the synthesis of amphidinolide B. An intramolecular stille coupling approach

A synthetic approach towards the cytotoxic polyene polyol macrolide amphidinolide B (1), based on elaboration of the C1-C13 carboxylic acid 4. and the C14-C25 alcohol 3 units, their esterification to the iodostannyl ester 2, and an intramolecular Stille sp2-sp2 coupling reaction, is described. In spite of adequate precedent and model experiments, circumstances conspired and the aforementioned coupling reaction was not realised in this case. (C) 2000 Elsevier Science Ltd.