121194-85-2

Basic information

• Product Name: 1,3-Dioxan-5-ol, 4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-phenyl-, (2R,4S,5R)-
• CAS NO: 121194-85-2
• Molecular Formula: C17H28O4Si
• Molecular Weight: 324.492
• Mol File: 121194-85-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxan-5-ol, 4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-phenyl-, (2R,4S,5R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxan-5-ol, 4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-phenyl-, (2R,4S,5R)-(121194-85-2)
• EPA Substance Registry System: 1,3-Dioxan-5-ol, 4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-phenyl-, (2R,4S,5R)-(121194-85-2)

Safety Data

• Hazardous Substances Data: 121194-85-2(Hazardous Substances Data)

Upstream product

• 117122-84-6 (2R,4S,5R)-2-phenyl-5-hydroxy-1,3-dioxane-4-methanol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 121194-86-3 (2R,4S,5R)-(-)-4-(t-butyldimethylsiloxymethyl)-2-phenyl-1,3-dioxan-5-yl bromoacetate 
• 121194-89-6 (6R,7R,8S,8aR,2'R,4'S,5'R)-(+)-4'-(t-butyldimethylsiloxymethyl)-2'-phenyl-1',3'-dioxan-5'-yl 6,7-bis-(3,4-dimethoxyphenyl)-5-oxoindolizidine-8-carboxylate 
• 390408-53-4 1,3-O-benzylidene-4-O-(tert-butyldimethylsilyl)-2-deoxy-L-erythritol 
• 874620-24-3 1,3-O-benzylidene-2-O-[(S-methylthio)thiocarbonyl]-4-O-(tert-butyldimethylsilyl)-L-erythritol 
• 121194-89-6 (6S,7R,8S,8aR)-6,7-Bis-(3,4-dimethoxy-phenyl)-5-oxo-octahydro-indolizine-8-carboxylic acid (2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxymethyl)-2-phenyl-[1,3]dioxan-5-yl ester 
• 121213-14-7 (E)-6-[(E)-2,3-Bis-(3,4-dimethoxy-phenyl)-acryloylamino]-hex-2-enoic acid (2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxymethyl)-2-phenyl-[1,3]dioxan-5-yl ester 
• 121194-87-4 (Triphenyl-λ⁵-phosphanylidene)-acetic acid (2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxymethyl)-2-phenyl-[1,3]dioxan-5-yl ester 

Relevant articles and documents

ASYMMETRIC TOTAL SYNTHESES OF (-)-TYLOPHORINE VIA THE HIGHLY ENANTIOSELECTIVE INTRAMOLECULAR DOUBLE MICHAEL REACTION

Asymmetric total synthesis of (-)-tylophorine (2) was achieved with a high enantioselectivity through the intramolecular double Michael reaction of the α , β -unsaturated ester (8) having a novel chiral auxiliary with tert.-butyldimethylsilyl trifluoromethanesulfonate and Et3N.

Asymmetric Total Synthesis of Naturally Occurring (R)-(-)-Enantiomer of Tylophorine via Intramolecular Double Michael Reaction

The first asymmetric total synthesis of the naturally occurring (R)-(-)-enantiomer (1) of tylophorine was achieved with high enantioselectivity via the intramolecular double Michael reaction of α,β-unsaturated esters (10) and (20), having two different chiral auxiliaries, with t-butyldimethylsilyl trifluoromethanesulphonate in the presence of triethylamine. (-)-Phenylmenthol and (2R,4S,5R)-(-)-4-(t-butyldimethylsiloxymethyl)-5-hydroxy-2-phenyl-1,3-dioxane, readily available from D-glucose, were used as chiral auxiliaries.