ASYMMETRIC TOTAL SYNTHESES OF (-)-TYLOPHORINE VIA THE HIGHLY ENANTIOSELECTIVE INTRAMOLECULAR DOUBLE MICHAEL REACTION

DOI: 10.1016/S0040-4039(00)80437-2

Source and publish data:

Tetrahedron Letters p. 4135 - 4138 (1988)

Update date:2022-08-03

Topics:

Authors:

Ihara, Masataka

Takino, Yoshinobu

Fukumoto, Keiichiro

Kametani, Tetsuji

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Article abstract of DOI:10.1016/S0040-4039(00)80437-2

Asymmetric total synthesis of (-)-tylophorine (2) was achieved with a high enantioselectivity through the intramolecular double Michael reaction of the α , β -unsaturated ester (8) having a novel chiral auxiliary with tert.-butyldimethylsilyl trifluoromethanesulfonate and Et3N.

Full text of DOI:10.1016/S0040-4039(00)80437-2

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