121194-90-9

Upstream product

• 52840-52-5 (E)-2,3-bis(3,4-dimethoxyphenyl)acrylic acid 
• 121194-88-5 (E)-2,3-bis-(3,4-dimethoxyphenyl)-N-(3-formylpropyl)acrylamide 
• 101537-87-5 (E)-N-(4,4-diethoxybutyl)-2,3-bis-(3,4-dimethoxyphenyl)-acrylamide 
• 121213-14-7 (E)-6-[(E)-2,3-Bis-(3,4-dimethoxy-phenyl)-acryloylamino]-hex-2-enoic acid (2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxymethyl)-2-phenyl-[1,3]dioxan-5-yl ester 
• 121194-89-6 (6R,7R,8S,8aR,2'R,4'S,5'R)-(+)-4'-(t-butyldimethylsiloxymethyl)-2'-phenyl-1',3'-dioxan-5'-yl 6,7-bis-(3,4-dimethoxyphenyl)-5-oxoindolizidine-8-carboxylate 

Downstream Products

• 121194-91-0 (6S,7R,8S,8aR)-(+)-methyl 6,7-bis-(3,4-dimethoxyphenyl)-5-oxoindolizidine-8-carboxylate 
• 482-20-2 (R)-tylophorine 

Relevant academic research and scientific papers

Asymmetric Total Synthesis of Naturally Occurring (R)-(-)-Enantiomer of Tylophorine via Intramolecular Double Michael Reaction

The first asymmetric total synthesis of the naturally occurring (R)-(-)-enantiomer (1) of tylophorine was achieved with high enantioselectivity via the intramolecular double Michael reaction of α,β-unsaturated esters (10) and (20), having two different chiral auxiliaries, with t-butyldimethylsilyl trifluoromethanesulphonate in the presence of triethylamine. (-)-Phenylmenthol and (2R,4S,5R)-(-)-4-(t-butyldimethylsiloxymethyl)-5-hydroxy-2-phenyl-1,3-dioxane, readily available from D-glucose, were used as chiral auxiliaries.