121196-97-2Relevant academic research and scientific papers
CONTINUOUS FLOW SYNTHESIS OF AMINO ALCOHOLS USING MICROREACTORS
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Page/Page column 9-10, (2011/06/10)
The present invention provides various methods for the synthesis of chemical species in a microreactor environment. In some cases, reaction products of the present invention may be valuable as intermediates and/or products in pharmaceutical and polymer research. For example, the method may involve the synthesis of amino alcohols within a microchannel. Embodiment described herein may allow for reactions with significantly shorter reaction times and increased efficiency.
Aminolysis of epoxides in a microreactor system: A continuous flow approach to β-Amino alcohols
Jensen, Klavs F.,Bedore, Matthew W.,Zaborenko, Nikolay,Jamison, Timothy F.
experimental part, p. 432 - 440 (2011/04/22)
The use of a continuous flow microreactor for β-amino alcohol formation by epoxide aminolysis is evaluated. Comparison to microwave batch reactions reveals that conditions obtainable in the microreactor can match or improve yields in many cases. By increasing the pressure of the system, maximum temperatures can also exceed those accessible using a microwave unit. The use of a microreactor for epoxide aminolysis reactions in the synthesis of two pharmaceutical relevant compounds is described.
