1212-30-2

Usage

Uses

Used in Analytical Chemistry:
1,3-Bis(2-pyridyl)thiourea is used as a chelating agent for metal ions, particularly for copper, in analytical chemistry. Its ability to form stable complexes with metal ions makes it a valuable tool for the detection and analysis of these elements.
Used in Organic Synthesis:
As a reagent in organic synthesis, 1,3-Bis(2-pyridyl)thiourea plays a crucial role in various chemical reactions. Its unique structure allows it to participate in the formation of new compounds, contributing to the advancement of organic chemistry.
Used in Coordination Chemistry:
In the field of coordination chemistry, 1,3-Bis(2-pyridyl)thiourea is used to form complexes with metal ions. These complexes are of interest for their potential applications in catalysis and material science.
Used in Material Science:
1,3-Bis(2-pyridyl)thiourea's structure and properties make 1,3-Bis(2-pyridyl)thiourea useful in material science. Its ability to form stable complexes with metal ions can lead to the development of new materials with unique properties.
Used in Pharmaceutical Industry:
1,3-Bis(2-pyridyl)thiourea has potential applications in the pharmaceutical industry due to its ability to form complexes with metal ions. This property could be harnessed for the development of new drugs or drug delivery systems that target specific metal ion interactions in biological systems.

InChI:InChI=1/C11H10N4S/c16-11(14-9-5-1-3-7-12-9)15-10-6-2-4-8-13-10/h1-8H,(H2,12,13,14,15,16)

Upstream product

• 504-29-0 2-aminopyridine 
• 75-15-0 carbon disulfide 
• 463-71-8 thiophosgene 
• 462-08-8 pyridin-3-ylamine 
• 74734-11-5 1H-imidazole-1-carbodithioic acid methyl ester 
• 110-86-1 pyridine 
• 109-09-1 2-chloropyridine 
• 4314-19-6 bis(1H-benzo[d][1,2,3]triazol-1-yl)methanethione 

Downstream Products

• 52648-45-0 2-pyridylisothiocyanate 
• 6268-43-5 1,3-di-pyridin-2-yl-urea 
• 101891-48-9 N-(4-ethoxy-phenyl)-N',N''-di-[2]pyridyl-guanidine 
• 88012-23-1 N-Phenyl-N',N''-dipyrid-2-yl-guanidin 
• 101735-02-8 4-(N',N''-di-[2]pyridyl-guanidino)-2-hydroxy-benzoic acid 
• 101570-52-9 N-(4-hydroxy-phenyl)-N',N''-di-[2]pyridyl-guanidine 
• 102558-80-5 N-(4-hexyloxy-phenyl)-N',N''-di-[2]pyridyl-guanidine 
• 102895-79-4 N-(4-octyloxy-phenyl)-N',N''-di-[2]pyridyl-guanidine 
• 102556-95-6 N-(4-pentyloxy-phenyl)-N',N''-di-[2]pyridyl-guanidine 
• 102460-93-5 N-(4-propoxy-phenyl)-N',N''-di-[2]pyridyl-guanidine 
• 103208-79-3 N-(4-dodecyloxy-phenyl)-N',N''-di-[2]pyridyl-guanidine 
• 102374-06-1 N-(4-butoxy-phenyl)-N',N''-di-[2]pyridyl-guanidine 

Relevant academic research and scientific papers

Axially chiral pyridine compounds: Synthesis, chiral separations and determination of protonation dependent barriers to hindered rotation

Axially chiral enantiomeric 2-pyridylimino-3-pyridyl-thiazolidine-4-ones and -thiones have been synthesized and their rotational barriers around the N-3C(pyridyl) bond have been determined by variable temperature NMR or by thermal racemization of the micropreparatively resolved enantiomers. Rotational barriers of the unprotonated compounds ranged from 46 to 116 kJ/mol, depending on the substituent on the N-3-pyridyl ring and on the exocyclic oxygen or sulfur atoms of the thiazolidine ring. Protonation of the pyridine nitrogens by TFA caused a decrease in the barrier to the rotation by stabilizing the transition state of the rotations via hydrogen bonding interactions.

Pt(II), Pd(II) and UO2(II) complexes of N,N′-bis(2- pyridyl)thiourea; Structural, thermal and biological studies

Novel complexes of Pt2+, Pd2+ and UO2 2+ with N,N′-bis(2-pyridyl)thiourea (H2BPT) 1 were synthesized. These complexes namely [Pt(HBPT)2] 2, [Pd(HBPT) 2] 3 and [UO2(HBPT)(OAc)(H2O)] 4 , were characterized by elemental analysis and spectral measurements. Suggested structures (square-planar for both 2 and 3 complexes and pentagonal-bipyramidal geometry for 4) were confirmed by applying geometry optimization and conformational analysis. Thermal properties and decomposition kinetics of all compounds are investigated. The interpretation, mathematical analysis and evaluation of kinetic parameters (E, A, ΔH, ΔS and ΔG) of all thermal decomposition stages have been evaluated using Coats-Redfern, Horowitz-Metzger and MKN Methods: The biochemical studies showed that, complex 2 has powerful and complete degradation effect on DNA. The antibacterial screening demonstrated that, complex 2 has the maximum and broad range activities against Gram-positive and Gram-negative bacterial strains.

Synthesis and characterization of binary and ternary oxovanadium complexes of N,N′-(2-pyridyl)thiourea and curcumin: Catalytic oxidation potential, antibacterial, antimicrobial, antioxidant and DNA interaction studies

Two binary and two ternary mono-oxovanadium (IV) complexes of acetylacetonate, curcumin and N,N′-bis(2-pyridyl)thiourea were synthesized. They were characterized using elemental analysis, infrared and UV–visible spectroscopies and magnetic and conductivity measurements. The formation constants Kf were determined from spectrophotometric measurements. The catalytic potential of the VO complexes was investigated for the oxidation of 1-octene by aqueous H2O2 in acetonitrile. They display high catalytic potential for the conversion of 1-octene with low chemoselectivity to the epoxy product. The VO complexes exhibit good antibacterial and antimicrobial activities. The antioxidant activity of the VO complexes and their ligands was investigated. The VO complexes show high DNA affinity and DNA cleavage ability.

Synthesis of thioureas in ionic liquid medium

A highly efficient procedure for the synthesis of symmetrical thioureas by means of simple condensation of primary amines and carbon disulfide in 1-butyl-3-methylimidazolium chloride [BMIM][Cl] as a cheap and commercially available ionic liquid is presented. This procedure works for aromatic and aliphatic primary amines and give high to excellent yields of symmetrical thioureas without need for any catalyst or tedious work-up.

New potent imidazoisoquinolinone derivatives as anti-Trypanosoma cruzi agents: Biological evaluation and structure-activity relationships

A series of novel benzoimidazo and N-aryl-5-oxo-imidazo[1,2-b]isoquinoline-10-carbothioamides was developed. All the compounds were evaluated for their in vitro action against the epimastigote form of Trypanosoma cruzi. Four of them showed higher activity than Nifurtimox. Their unspecific cytotoxicity was evaluated using HeLa and L6 cells, being non-toxic at concentrations at least 15 and 200 times higher than that of T. cruzi IC50. To gain insight into the mechanism of action, their DNA binding properties and reactivity with glutathione were studied, and QSAR study was performed.

Hydrogen-bonding networks in heterocyclic thioureas

The synthesis of heterocyclic thioureas from heterocyclic amines with phenyl- or methylisothiocyanate or CS2 is described. Seven new X-ray crystal structures are reported: In N-(3-pyridyl)-N'-phenylthiourea (Pna2 1, a = 10.1453(3), b

Benzotriazole-assisted thioacylation

Benzotriazole reagents for thioacylation (RCSBt), thiocarbamoylation (RR'NCSBt), aryl/alkoxy-thioacylation (ROCSBt), and aryl/alkylthiothioacylation (RSCSBt) are synthesized, and their utility is assessed by syntheses of representative heteroaryl thioureas 3a-g, thioamides 15a-s, thionoesters 16a-h, thiocarbamates 17a-e, dithiocarbamates 18a-d, thiocarbonates 19a-c, and dithiocarbonates 20a-c.

N,N′-Dipyridylthiourea as a new sensitive reagent for the extraction and spectrophotometric determination of osmium(VI) and iridium(III)

N,N′-Dipyridylthiourea (DPyT) reacts with OsVI and Ir III forming coloured extractable complexes (λmax 355 nm in chloroform: ethanol for Os complex and 335 nm for Ir complex in the same extractant). In presence of moderate excess of diverse ions both Os and Ir can be determined with DPyT in ppm level. The molar extinction coefficient and Sandell's sensitivity values for OsVI and IrIII complexes are 3.05 × 104, 0.006 and 1.89 × 104 dm 3 mol-1 cm-1 and 0.01 μg cm-2, respectively. The Os and Ir complexes have 1:2 and 1:3 M:R stoichiometries respectively.

1-(Methyldithiocarbonyl)imidazole: A useful thiocarbonyl transfer reagent for synthesis of substituted thioureas

1-(Methyldithiocarbonyl)imidazole 1 and its N-methyl quaternary salt 2 have been shown to be efficient methyldithiocarbonyl and thiocarbonyl transfer reagents for the synthesis of dithiocarbamates, symmetrical and unsymmetrical mono-, di- and tri-substituted thioureas in high yields under mild and simple non-hazardous reaction conditions. (C) 2000 Elsevier Science Ltd.