1212-48-2Relevant articles and documents
Synthesis method of dibazolum
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Paragraph 0024; 0025; 0026; 0027, (2017/01/17)
The invention provides a synthesis method of dibazolum. The synthesis method comprises the following steps: adding o-phenylenediamine and toluene into a reaction container; dropwise adding phenylacetyl chloride into the reaction container; after dripping, heating and reflowing to react until the reaction is finished; carrying out post-treatment to obtain a dibazolum product. Compared with the prior art, the synthesis method has the following beneficial technical effects that (1) the reaction temperature is reduced so that a reaction for synthesizing the dibazolum can be carried out under a moderate condition; (2) any hydration agent or any catalyst is not added in the synthesis method and side reactions are few, so that impurities are effectively reduced and the number of times of subsequent de-coloring and crystallization is reduced; (3) post-treatment operation is simplified by the synthesis method so that the production cost is saved and large-scale and industrial production is facilitated.
Synthesis of nitrogenous heterocycles under microwave activation
El'tsov,Sokolova,Dmitrieva,Grigor'ev,Ivanov
, p. 1317 - 1320 (2007/10/03)
Microvawe activation accelerates heterocyclization of o-phenylenediamine with phenylacetic acid with benzyl cyanide tens times, simultaneously improving the yield and quality of the resulting 2-benzyl-imidazole. The effect of microwave activation on heterocyclization of ethyl(phenyl)malonic acid with formic acid or its amide is not so strong.
