121209-54-9Relevant academic research and scientific papers
Methylenecyclopropanes, XI. - Asymmetric Nickel(0)-Catalyzed Cycloadditions of Methylenecyclopropanes with Chiral Derivatives of Acrylic Acid
Binger, Paul,Brinkmann, Axel,Roefke, Petra,Schaefer, Bernd
, p. 739 - 750 (2007/10/02)
The nickel(0)-catalyzed codimerisation of methylenecyclopropane 1a or 2,2-dimethylmethylenecyclopropane (1b) with the chiral derivatives of acrylic acid 2a-2f leads to the optically active 3-methylenecyclopentanecarboxylic esters 3a, 3c-3f, 4a, and 4c, or amides 3b and 4b in good yields.The diastereomeric excess accesible depends on the steric demand of the chiral auxiliaries, de values up to 98percent can be achieved.Some improvements of the preparation of optically pure auxiliaries are also described.
