1212152-78-7

Basic information

• Product Name: (2S)-3-phenyl-2-(1H-tetraazol-1-yl)propanoic acid
• Synonyms: (2S)-3-phenyl-2-(1H-tetraazol-1-yl)propanoic acid;(2S)-3-Phenyl-2-(1H-1,2,3,4-tetrazol-1-yl)propanoic acid;(S)-3-phenyl-2-(1H-tetrazol-1-yl)propanoic acid
• CAS NO: 1212152-78-7
• Molecular Formula: C₁₀H₁₀N₄O₂
• Molecular Weight: 218.212
• Mol File: 1212152-78-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2S)-3-phenyl-2-(1H-tetraazol-1-yl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-3-phenyl-2-(1H-tetraazol-1-yl)propanoic acid(1212152-78-7)
• EPA Substance Registry System: (2S)-3-phenyl-2-(1H-tetraazol-1-yl)propanoic acid(1212152-78-7)

Safety Data

• Hazardous Substances Data: 1212152-78-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(2S)-3-phenyl-2-(1H-tetraazol-1-yl)propanoic acid is used as a therapeutic agent for the treatment of diabetes, metabolic syndrome, and cardiovascular diseases. Its ability to activate PPARs aids in the regulation of genes involved in metabolism, which can help manage these conditions.
Used in Oncology:
(2S)-3-phenyl-2-(1H-tetraazol-1-yl)propanoic acid is used as a potential anticancer agent. Its pharmacological properties may contribute to the development of treatments for various types of cancer.
Used in Anti-inflammatory Applications:
(2S)-3-phenyl-2-(1H-tetraazol-1-yl)propanoic acid is used as an anti-inflammatory agent. Its potential to modulate inflammation-related genes could be beneficial in the treatment of inflammatory conditions.
Used in Drug Development Research:
(2S)-3-phenyl-2-(1H-tetraazol-1-yl)propanoic acid is used as a research compound for studying its pharmacological activities and potential applications in drug development. Its wide range of effects on PPARs and other biological processes makes it a valuable candidate for further investigation into new therapeutic strategies.

Upstream product

• 1101195-47-4 (1S)-1-(4-methyl-2,6,7-trioxabicyclo[2.2.2]oct-1-yl)-2-phenylethyl isocyanide 
• 63-91-2 L-phenylalanine 
• 122-51-0 orthoformic acid triethyl ester 

Relevant articles and documents

Copper nanoparticles: A capable and versatile catalyst for the synthesis of diverse 1-phenyl-1H-tetrazoles from amino acids

Cu nanoparticles were prepared in successive stages: preparation of the Fe3O4 magnetic nanoparticles (Fe3O4 MNPs), coating of the Fe3O4 MNPs with tetraethyl orthosilicate (Fe3Os

Synthesis of chiral α-(tetrazol-1-yl)-substituted carboxylic acids

Optically active α-(tetrazol-1-yl)-substituted carboxylic acid OBO-esters were synthesized from the corresponding a-isocyano OBO-esters and trimethylsilyl azide in up to 92% yield. Subsequent acidic hydrolysis proceeds without epimerization and makes it p

Synthesis of new 1-substituted-1h-1,2,3,4-tetrazoles from l-α-amino acids and their biological assays

A new series of 1-substituted 1H-1,2,3,4-tetrazoles was synthesized from the reaction of L-α-amino acids, triethylorthoformate and sodium azide in glacial acetic acid at 80 °C in good yields (55-80 %). Not only acetic acid is a good solvent but also an effective catalyst promoting the reaction compared with the Lewis acids/microwave, Lewis acids/ ultrasonic or Lewis acids/solvent-free conditions to give the corresponding 1H-1,2,3,4-tetrazoles. Also, the antimicrobial activity investigations (antibacterial activity against E. coli and antifungal activity against Candida albicans) showed that all the tetrazoles obtained were inactive except the one obtained from tryptophan. In addition, the obtained 1- substituted 1H-1,2,3,4-tetrazoles were resistant in different reducing and oxidizing conditions.