121221-68-9

Basic information

• Product Name: (1SR, 5RS, 6RS, 7RS)-7-tert-butyldimethylsilyloxy-6-<(3RS)-3-tert-butyldimethylsilyloxy-4-(3-chlorophenoxy)but-1(E)-en-1-yl>-2-oxabicyclo<3.3.0>octan-3-one
• Synonyms: (1SR, 5RS, 6RS, 7RS)-7-tert-butyldimethylsilyloxy-6-<(3RS)-3-tert-butyldimethylsilyloxy-4-(3-chlorophenoxy)but-1(E)-en-1-yl>-2-oxabicyclo<3.3.0>octan-3-one
• CAS NO: 121221-68-9
• Molecular Weight: 567.313
• Mol File: 121221-68-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1SR, 5RS, 6RS, 7RS)-7-tert-butyldimethylsilyloxy-6-<(3RS)-3-tert-butyldimethylsilyloxy-4-(3-chlorophenoxy)but-1(E)-en-1-yl>-2-oxabicyclo<3.3.0>octan-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1SR, 5RS, 6RS, 7RS)-7-tert-butyldimethylsilyloxy-6-<(3RS)-3-tert-butyldimethylsilyloxy-4-(3-chlorophenoxy)but-1(E)-en-1-yl>-2-oxabicyclo<3.3.0>octan-3-one(121221-68-9)
• EPA Substance Registry System: (1SR, 5RS, 6RS, 7RS)-7-tert-butyldimethylsilyloxy-6-<(3RS)-3-tert-butyldimethylsilyloxy-4-(3-chlorophenoxy)but-1(E)-en-1-yl>-2-oxabicyclo<3.3.0>octan-3-one(121221-68-9)

Safety Data

• Hazardous Substances Data: 121221-68-9(Hazardous Substances Data)

Upstream product

• 52267-81-9 <3aα,4α,5β,6aα>-(+/-)-hexahydro-5-hydroxy-4-<(E)-4-(3-chlorophenoxy)-(3α)-hydroxy-1-butenyl>-2H-cyclopentafuran-2-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 121221-70-3 methyl 2-<(1SR, 3SR, 5RS, 6RS, 7RS)-7-tert-butyldimethylsilyloxy-6-<(3RS)-3-tert-butyldimethylsilyloxy-4-(3-chlorophenoxy)but-1(E)-en-1-yl>-2-oxabicyclo<3.3.0>oct-3-yl>acetate 
• 121221-69-0 (1SR, 5RS, 6RS, 7RS)-7-tert-butyldimethylsilyloxy-6-<(3RS)-3-tert-butyldimethylsilyloxy-4-(3-chlorophenoxy)but-1(E)-en-1-yl>-2-oxabicyclo<3.3.0>octan-3ξ-ol 

Relevant articles and documents

Prostaglandins and Prostaglandin Intermediates. 22 - Synthesis of a Stable Prostacyclin Analogue

An industrially available prostaglandin intermediate is converted into a new prostacyclin analogue with a cyclic ether instead of the unstable enol ether system.For the construction of the modified alkyl side chain two subsequent Horner olefinations are used.This reaction sequence includes a new methodology for the conversion of an aldehyde into a β,γ-unsaturated carboxylic acid by a three-carbon elongation.