121224-60-0

Basic information

• Product Name: (R)-2-Acetyl-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-3-(3,4,5-trimethoxy-phenyl)-pentanedioic acid 5-tert-butyl ester 1-ethyl ester
• CAS NO: 121224-60-0
• Molecular Weight: 606.757
• Mol File: 121224-60-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-Acetyl-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-3-(3,4,5-trimethoxy-phenyl)-pentanedioic acid 5-tert-butyl ester 1-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-Acetyl-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-3-(3,4,5-trimethoxy-phenyl)-pentanedioic acid 5-tert-butyl ester 1-ethyl ester(121224-60-0)
• EPA Substance Registry System: (R)-2-Acetyl-4-{1-[(E)-(S)-2-(1-methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-ethyl}-3-(3,4,5-trimethoxy-phenyl)-pentanedioic acid 5-tert-butyl ester 1-ethyl ester(121224-60-0)

Safety Data

• Hazardous Substances Data: 121224-60-0(Hazardous Substances Data)

Upstream product

• 121224-35-9 (S)-(-)-1-amino-2-(1'-methoxy-1'-methylethyl)pyrrolidine 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 1694-31-1 tert-butyl acetoacetate 
• 104990-27-4 ethyl 2-[1-(2,3,4-trimethoxyphenyl)-methylidene]-3-oxobutyrate 
• 121224-37-1 3-[(E)-(S)-2-(1-Methoxy-1-methyl-ethyl)-pyrrolidin-1-ylimino]-butyric acid tert-butyl ester 

Downstream Products

• 121224-54-2 (R)-2,6-Dimethyl-4-(3,4,5-trimethoxy-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-tert-butyl ester 5-ethyl ester 
• 121224-54-2 (S)-2,6-Dimethyl-4-(3,4,5-trimethoxy-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-tert-butyl ester 5-ethyl ester 

Relevant articles and documents

ENANTIOSELECTIVE HANTZSCH DIHYDROPYRIDINE SYNTHESIS VIA METALATED CHIRAL ALKYL ACETOACETATE HYDRAZONES

An efficient, overall enantioselective variant of the Hantzsch synthesis of 4-aryl-1,4-dihydropyridines 5 (ee = 84 - 98percent), important biologically active compounds (e. g. as calcium channel blockers), is described.Key step of the new procedure is the