121224-96-2Relevant academic research and scientific papers
An unusual and efficient reaction of 2-methylene-3-phenyloxetane in the presence of lithium and 4,4'-di-tert-butylbiphenyl in THF
Hashemzadeh, Mehrnoosh,Howell, Amy R.
, p. 1859 - 1862 (2000)
When 2-methylene-3-phenyloxetane (4) was treated with excess lithium and DTBB (cat.), lactone 6 was isolated as an unexpected product in high yield. It is postulated that 6 arises from a coupling of a radical enolate derived from 4 and the enolate of acetaldehyde, a product of THF decomposition under the reaction conditions. (C) 2000 Elsevier Science Ltd.
Palladium(0)-catalyzed coupling cyclization of functionalized allenes with hypervalent iodonium salts
Kang, Suk-Ku,Baik, Tae-Gon,Kulak, Alexander N.
, p. 324 - 326 (1999)
The palladium(0)-catalyzed coupling reaction of allenic alcohols, amines, acids with hypervalent iodonium salts afforded the cyclized heterocyclic tetrahydrofurans, tetrahydropyrans, pyrrolidines, piperidines, or lactones under mild conditions.
SYNTHESIS OF VINYLIC LACTONES VIA PALLADIUM-CATALYZED COUPLING OF VINYLIC HALIDES OR TRIFLATES AND UNSATURATED CARBOXYLIC ACIDS
Larock, Richard C.,Leuck, David J.,Harrison, L. Wayne
, p. 6399 - 6402 (2007/10/02)
Vinylic halides or triflates react with 3-butenoic or 4-pentenoic acids in the presence of 5percent Pd(OAc)2 or Pd(dba)2, n-Bu4NCl, i-PrNEt and either acetonitrile or N,N-dimethylformamide at 80-100 deg C to afford the corresponding γ-alkenyl-γ-butyro- or
