121269-56-5Relevant articles and documents
Synthesis of α-Alkyl-α-Benzyl Amino Acid Derivatives, via the Diastereoselective Alkylation of (3S,5R)-N,3-Dibenzyl-3,4,5,6-tetrahydro-5-phenyl-1,4-oxazin-2-one
Boa, Andrew N.,Guest, Amanda L.,Jenkins, Paul R.,Fawcett, John,Russell, David R.,Waterson, David
, p. 477 - 482 (2007/10/02)
(3S,5R)-N,3-Dibenzyl-3,4,5,6-tetrahydro-5-phenyl-1,4-oxazin-2-one, derived from L-phenylalanine and phenacyl bromide, was alkylated in a diastereoselective manner to give a range of α-alkylated phenylalanine derivatives.
STEREOSELECTIVE ALKYLATION OF CHIRAL GLYCINE ENOLATE SYNTHONS. THE ENANTIOSELECTIVE SYNTHESIS O α-AMINO ACID DERIVATES
Dellaria, Joseph F.,Santarsiero, Bernard D.
, p. 6079 - 6082 (2007/10/02)
The highly stereoselective alkylation (percentde=99.6 to 97.6) o a new chiral glycine enolate synthon derived from D-2-phenylglycinol is described.Deprotection of the alkylation adducts in a one-pot, three-step procedure provides the ethyl ester hydrochloride salts of the corresponding α-amino acids with no attending racemization.