1213137-26-8

Basic information

• Product Name: (1S)-2,2,2-TRIFLUORO-1-(3-METHOXYPHENYL)ETHYLAMINE
• Synonyms: (1S)-2,2,2-TRIFLUORO-1-(3-METHOXYPHENYL)ETHYLAMINE;(S)-2,2,2-TRIFLUORO-1-(3-METHOXY-PHENYL)-ETHYLAMINE
• CAS NO: 1213137-26-8
• Molecular Formula: C₉H₁₀F₃NO
• Molecular Weight: 205.18
• Mol File: 1213137-26-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1S)-2,2,2-TRIFLUORO-1-(3-METHOXYPHENYL)ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (1S)-2,2,2-TRIFLUORO-1-(3-METHOXYPHENYL)ETHYLAMINE(1213137-26-8)
• EPA Substance Registry System: (1S)-2,2,2-TRIFLUORO-1-(3-METHOXYPHENYL)ETHYLAMINE(1213137-26-8)

Safety Data

• Hazardous Substances Data: 1213137-26-8(Hazardous Substances Data)

Usage

General Description

(1S)-2,2,2-TRIFLUORO-1-(3-METHOXYPHENYL)ETHYLAMINE is a chemical compound with the molecular formula C9H10F3NO. It is an amine compound that contains a trifluoroethyl group and a methoxyphenyl group. (1S)-2,2,2-TRIFLUORO-1-(3-METHOXYPHENYL)ETHYLAMINE is a chiral molecule with a single chiral center, resulting in two enantiomers. It can be used as a building block in organic synthesis and pharmaceutical research. Its properties and potential applications make it a valuable compound in the field of medicinal chemistry and drug development.

Upstream product

• 1223578-81-1 (R(S),S)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]-2-propanesulfinamide 
• 30724-22-2 2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone 
• 1334287-91-0 4-methoxy-N-(2,2,2-trifluoro-1-(3-methoxyphenyl)ethylidene)aniline 
• 1334287-98-7 (S)-4-methoxy-N-(2,2,2-trifluoro-1-(3-methoxyphen-yl)ethyl)aniline 

Downstream Products

• 1223578-77-5 (S)-3-(2-chlorophenyl)-N-[2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl]propanamide 
• 1223578-79-7 (S)-3-(2-chlorophenyl)-N-(2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl)-propan-1-amine 

Relevant articles and documents

Catalytic Asymmetric Reduction of α-Trifluoromethylated Imines with Catecholborane by BINOL-Derived Boro-phosphates

A catalytic enantioselective reduction of α-trifluoromethylated imines by a BINOL-derived boro-phosphate employing catecholborane as hydride source has been developed. This method provides an efficient route to prepare synthetically useful chiral α-triflu

Enantiodivergent approach to trifluoromethylated amines: A concise route to both enantiomeric analogues of calcimimetic NPS R-568

Reported herein is a straightforward and enantiodivergent synthesis of both enantiomers of trifluoromethylated analogues of calcimimetic NPS R-569 in a highly estereoselective manner. The synthesis features a diastereoselective synthesis of the N-(isopropylsulfinyl)imine unit by the "DAG methodology" and a diastereoselective addition of Ruppert Prakash's reagent to the imine as the key steps. No protecting groups were necessary, permitting an atom economic synthesis in only six steps. Further addition reactions of the CF3 anion to different N-(isopropylsulfinyl)imines were performed to demonstrate the suitability of the sulfinyl substituent to balance perfectly reactivity and diastereoselectivity.