1213240-82-4

Basic information

• Product Name: 2-(5-fluoro-2-methoxyphenyl)-8,9-dimethoxy-1-(3,4,5-trimethoxyphenyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline
• CAS NO: 1213240-82-4
• Molecular Weight: 519.57
• Mol File: 1213240-82-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(5-fluoro-2-methoxyphenyl)-8,9-dimethoxy-1-(3,4,5-trimethoxyphenyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-fluoro-2-methoxyphenyl)-8,9-dimethoxy-1-(3,4,5-trimethoxyphenyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline(1213240-82-4)
• EPA Substance Registry System: 2-(5-fluoro-2-methoxyphenyl)-8,9-dimethoxy-1-(3,4,5-trimethoxyphenyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline(1213240-82-4)

Safety Data

• Hazardous Substances Data: 1213240-82-4(Hazardous Substances Data)

Upstream product

• 108704-76-3 6,7-dimethoxy-1-(3,4,5-trimethoxybenzyl)-3,4-dihydroisoquinoline hydrochloride 
• 343-04-4 2-bromo-1-(5-fluoro-2-methoxyphenyl)ethan-1-one 

Relevant articles and documents

Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents

A new series of hybrids of lamellarin D and combretastatin A 4, 1,2-diphenyl-5,6-dihydropyrrolo [2,1-a] isoquinolines, were designed as cytotoxic agents based on principles of combination in medicinal chemistry and taking the parent compounds' different anti-proliferative mechanisms into consideration. Twenty-two novel hybrids were synthesized through a convenient route, with a key step of core pyrrole formation and evaluated for their anti-proliferative activities in vitro against K-562, A-549, SMMC-7721, SGC-7901 and HCT-116 cancer cell lines. The results showed that some hybrids had good anti-proliferative activities in low IC50 ranges.