343-04-4

Usage

Uses

Used in Pharmaceutical Industry:
2-BROMO-1-(5-FLUORO-2-METHOXYPHENYL)ETHANONE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-BROMO-1-(5-FLUORO-2-METHOXYPHENYL)ETHANONE is employed as a building block in the creation of agrochemicals, contributing to the development of effective compounds for agricultural use.
Used in Fine Chemicals Industry:
This versatile compound is also used as an intermediate in the production of fine chemicals, where its unique structure allows for the synthesis of high-quality specialty chemicals.
Used in Research and Development:
2-BROMO-1-(5-FLUORO-2-METHOXYPHENYL)ETHANONE is utilized in research and development settings as a valuable intermediate for creating new compounds with potential applications in various fields, including medicine, agriculture, and other industries.

Upstream product

• 459-60-9 1-fluoro-4-methoxybenzene 
• 598-21-0 2-Bromoacetyl bromide 
• 445-82-9 1-(5-fluoro-2-methoxyphenyl)ethanone 

Downstream Products

• 801154-59-6 1-(5-fluoro-2-methoxy-phenyl)-2-(2-imino-thiazolidin-3-yl)-ethanone 
• 1547-71-3 [4-(5-fluoro-2-methoxy-phenyl)-thiazol-2-yl]-phenyl-amine 
• 887591-34-6 C₁₀H₈FNO₂ 
• 1213240-84-6 2-(5-fluoro-2-methoxyphenyl)-8,9-dimethoxy-1-(4-methoxyphenyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline 
• 1213240-83-5 2-(5-fluoro-2-methoxyphenyl)-8-isopropoxy-1-(4-isopropoxy-3-methoxyphenyl)-9-methoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline 
• 1213240-82-4 2-(5-fluoro-2-methoxyphenyl)-8,9-dimethoxy-1-(3,4,5-trimethoxyphenyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline 
• 6752-10-9 2-(2-acetylimino-thiazolidin-3-yl)-1-(5-fluoro-2-methoxy-phenyl)-ethanol 
• 934340-27-9 C₁₃H₁₂FNO₄ 

Relevant academic research and scientific papers

Preparation method of 2-methoxy-5-fluorobromoacetophenone

The invention discloses a preparation method of 2-methoxy-5-fluorobromoacetophenone. The method comprises the following steps: taking p-fluoroanisole as an initial raw material, and reacting with bromoacetyl bromide under the condition of Lewis acid to generate a compound I, namely 2-methoxy-5-fluorobromoacetophenone. In the one-step synthesis route process taking the p-fluoroanisole as the initial raw material, a large amount of reagents with high toxicity and high pollution are avoided, and meanwhile, the raw materials are low in price, so that the whole synthesis process is low in pollution and easy to treat.

ROR-GAMMA INHIBITORS

The present invention relates to compounds of formula I and pharmaceutical compositions comprising compounds of formula I. Compounds of Formula I are useful in treatment of inflammatory, metabolic or autoimmune diseases which are mediated by RORy.

Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents

A new series of hybrids of lamellarin D and combretastatin A 4, 1,2-diphenyl-5,6-dihydropyrrolo [2,1-a] isoquinolines, were designed as cytotoxic agents based on principles of combination in medicinal chemistry and taking the parent compounds' different anti-proliferative mechanisms into consideration. Twenty-two novel hybrids were synthesized through a convenient route, with a key step of core pyrrole formation and evaluated for their anti-proliferative activities in vitro against K-562, A-549, SMMC-7721, SGC-7901 and HCT-116 cancer cell lines. The results showed that some hybrids had good anti-proliferative activities in low IC50 ranges.

3-Substituted-(5-arylfuran-2-ylcarbonyl)guanidines as NHE-1 inhibitors

The C-3 substituents effect on NHE-1 inhibitory activity of (5-arylfuran-2-ylcarbonyl)guanidines, previously identified as potent NHE-1 inhibitors, was investigated. The introduction of amine or alkyl groups at the 3-position of the furan ring, next to the acylguanidine moiety, remarkably improves NHE-1 inhibitory potency. Especially the important finding is that 5-(2,5-dichloro)phenyl and 5-(2-methoxy-5-chloro)phenyl derivatives exhibit high NHE-1 inhibitory activities (IC50 0.02 μM) that match those of 3-unsubstituted derivatives.