1213262-03-3Relevant academic research and scientific papers
BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS
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Page/Page column 52-53, (2010/04/06)
Novel benzo[d]oxazole and/or benzo[d]thiazole compounds, pharmaceutical compositions containing the benzo[d]oxazole and/or benzo[d]thiazole compounds, and methods of their pharmaceutical use are disclosed. In certain embodiments, the benzo[d]oxazole and/o
Benzimidazole- and benzoxazole-based inhibitors of Rho kinase
Sessions, E. Hampton,Yin, Yan,Bannister, Thomas D.,Weiser, Amiee,Griffin, Evelyn,Pocas, Jennifer,Cameron, Michael D.,Ruiz, Claudia,Lin, Li,Schuerer, Stephan C.,Schroeter, Thomas,LoGrasso, Philip,Feng, Yangbo
scheme or table, p. 6390 - 6393 (2009/09/06)
Inhibitors of Rho kinase have been developed based on two distinct scaffolds, benzimidazoles, and benzoxazoles. SAR studies and efforts to optimize the initial lead compounds are described. Novel selective inhibitors of ROCK-II with excellent potency in b
