1213263-06-9Relevant academic research and scientific papers
Evaluation of the biosynthetic proposal for the synthesis of marineosins A and B
Aldrich, Leslie N.,Dawson, Eric S.,Lindsley, Craig W.
supporting information; experimental part, p. 1048 - 1051 (2010/06/15)
Chemical equation presented The first synthetic efforts toward marlneosins A and B, novel spiroaminals from a Streptomyces actinomycete, are described by evaluation of the proposed biosynthesis. The hypothesized biosynthetlc C1-C25 Diels-Alder substrate was prepared In 8 steps in 5.1% overall yield; however, the proposed biomimetic inverse-electron-demand hetero-Diels-Alder reaction failed to deliver the marineosin core. Molecular mechanics supports this observation.
