86688-93-9Relevant academic research and scientific papers
Total Synthesis and Antimalarial Activity of 2-(p-Hydroxybenzyl)-prodigiosins, Isoheptylprodigiosin, and Geometric Isomers of Tambjamine MYP1 Isolated from Marine Bacteria
Kancharla, Papireddy,Li, Yuexin,Yeluguri, Monish,Dodean, Rozalia A.,Reynolds, Kevin A.,Kelly, Jane X.
, p. 8739 - 8754 (2021/06/30)
Highly efficient and straightforward synthetic routes toward the first total synthesis of 2-(p-hydroxybenzyl)-prodigiosins (2-5), isoheptylprodigiosin (6), and geometric isomers of tambjamine MYP1 ((E/Z)-7) have been developed. The crucial steps involved in these synthetic routes are the construction of methoxy-bipyrrole-carboxaldehydes (MBCs) and a 20-membered macrocyclic core and a regioselective demethylation of MBC analogues. These new synthetic routes enabled us to generate several natural prodiginines24-27in larger quantity. All of the synthesized natural products exhibited potent asexual blood-stage antiplasmodial activity at low nanomolar concentrations against a panel ofPlasmodium falciparumparasites, with a great therapeutic index. Notably, prodiginines6and24-27provided curative in vivo efficacy against erythrocyticPlasmodium yoeliiat 25 mg/kg × 4 days via oral route in a murine model. No overt clinical toxicity or behavioral change was observed in any mice treated with prodiginines and tambjamines.
Design, synthesis and biological evaluation of anti-pancreatic cancer activity of plinabulin derivatives based on the co-crystal structure
Fu, Zhangyu,Hou, Yingwei,Ji, Cunpeng,Ma, Mingxu,Tian, Zhenhua,Deng, Mengyan,Zhong, Lili,Chu, Yanyan,Li, Wenbao
, p. 2061 - 2072 (2018/03/26)
Based on the co-crystal structures of tubulin with plinabulin and Compound 1 (a derivative of plinabulin), a total of 18 novel plinabulin derivatives were designed and synthesized. Their biological activities were evaluated against human pancreatic cancer BxPC-3 cell lines. Two novel Compounds 13d and 13e exhibited potent activities with IC50 at 1.56 and 1.72 nM, respectively. The tubulin polymerization assay indicated that these derivatives could inhibit microtubule polymerization. Furthermore, the interaction between tubulin and these compounds were elucidated by molecular docking. The binding modes of Compounds 13d and 13e were similar to the co-crystal structure of Compound 1. H-π interaction was observed between the aromatic hydrogen of thiophene moiety with Phe20, which could enhance their binding affinities.
Magnesiation of N-Heterocycles Using i-PrMgCl · LiCl and catalytic diisopropylamine
Nxumalo,Dinsmore
supporting information, p. 2478 - 2484 (2015/11/10)
The direct magnesiation of various N-heterocyclic compounds with i-PrMgCl · LiCl and catalytic diisopropylamine allows for preparation of 2-substituted pyrroles, imidazole, indoles, and benzimidazoles, in moderate to good yields. The magnesiated substrates canreadily undergo a Kumada-type coupling with iodo-aryls in the presence of catalytic Pd(PPh3)4.
Application of a 6π-1-azatriene electrocyclization strategy to the total synthesis of the marine sponge metabolite ageladine A and biological evaluation of synthetic analogues
Meketa, Matthew L.,Weinreb, Steven M.,Nakao, Yoichi,Fusetani, Nobuhiro
, p. 4892 - 4899 (2008/02/05)
(Chemical Equation Presented) A 12-step synthesis of the angiogenesis inhibitory marine metabolite ageladine A is reported. The key steps include a 6π-1-azatriene electrocyclization for formation of the pyridine ring and a Suzuki-Miyaura coupling of N-Boc
Magnesiation Employing Grignard Reagents and Catalytic Amine. Application to the Functionalization of N-Phenylsulfonylpyrrole
Dinsmore, Andrew,Billing, David G.,Mandy, Karen,Michael, Joseph P.,Mogano, Daniel,Patil, Shivaputra
, p. 293 - 296 (2007/10/03)
(Matrix presented) N-Phenylsulfonylpyrrole 1 is magnesiated by treatment with isopropylmagnesium chloride and catalytic diisopropylamine. Reaction with various electrophiles, including palladium-catalyzed aryl- and heteroaryl cross-coupling, provides 2-su
Ring-deactivated hydroxymethylpyrroles as inhibitors of α-chymotrypsin
Abell, Andrew D.,Nabbs, Brent K.
, p. 621 - 628 (2007/10/03)
N-Acyl and N-sulfonylhydroxymetyhylpyrroles have been synthesised and shown to inhibit α-chymotrypsin. A hydrophobic group in the N-substituent has been shown to be required for activity. Copyright
PREPARATION OF ALKYL-SUBSTITUTED INDOLES IN THE BENZENE PORTION. Part 3
Muratake, Hideaki,Natsume, Mitsutaka
, p. 683 - 690 (2007/10/02)
Three-step synthesis of 7- and 4-alkyl-1-tosylindoles (9 and 10) was accomplished by combination of the Friedel-Crafts acylation of 4, and the treatment of 7 and 8 with H2SO4 in 2-propanol as illustrated in Chart 2.Further a novel synthetic method of 16 was devised from 14 by way of 15.
Pyrrole Studies; 34. Synthesis of 1,2-Di(2-pyrrolyl)ethenes and Related Compounds
Hinz, Werner,Jones, R. Alan,Anderson, Trevor
, p. 620 - 623 (2007/10/02)
Novel 1,2-di(2-pyrrolyl)ethenes 5 and related compounds 8 have been prepared in good yield using the Wittig reaction.Although the Horner reaction can be used for the synthesis of 1,2-di(2-thienyl)- and 1,2-di(2-furyl)-ethenes, the procedure is not suitabl
A CONVENIENT SYNTHESIS OF t-BUTYLDIMETHYLSILYL PROTECTED CYANOHYDRINS
Rawal, Viresh H.,Rao, J. Appa,Cava, Michael P.
, p. 4275 - 4278 (2007/10/02)
A simple high yielding procedure is described for the direct conversion of aldehydes to t-butyldimethylsilyl (TBS) protected cyanohydrins using TBSCl, KCN and ZnI2.
Regioselective Synthesis of Acylpyrroles
Kakushima, Masatoshi,Hamel, Pierre,Frenette, Richard,Rokach, Joshua
, p. 3214 - 3219 (2007/10/02)
The regioselective synthesis of several pyrrole derivatives is described.AlCl3-catalyzed acylation reactions of 1-(phenylsulfonyl)pyrrole (1) give 3-acyl derivatives, whereas the corresponding BF3*OEt2-catalyzed reactions give 2-acyl derivatives predominantly.Mild alkaline hydrolysis gives the corresponding acyl-1H-pyrroles in excellent yields.AlCl3-catalyzed reactions of 1 with 1,1-dichloromethyl methyl ether and oxalyl chloride give 1-(phenylsulfonyl)-2-formylpyrrole (6) and 1-(phenylsulfonyl)-2-(chlorocarbonyl)pyrrole (7), respectively. 3-Pyrrolylacetic acid (10) was prepared by thallium(III) nitrate promoted rearrangement of 1-(phenylsulfonyl)-3-acetylpyrrole (2a).Trifluoroacetic anhydride catalyzed cyclization of 4-butyric acid (14) gives 1-(phenylsulfonyl)-7-oxo-4,5,6,7-tetrahydroindole (17).Attempts to cyclize 14 at the 4-position have been unsuccessful.
