121353-87-5Relevant articles and documents
3',3'-Difluoro-3'-deoxythymidine: Comparison of anti-HIV activity to 3'- fluoro-3'-deoxythymidine
Bergstrom,Mott,De Clercq,Balzarini,Swartling
, p. 3369 - 3372 (1992)
3',3'-Difluoro-3'-deoxythymidine (3) has been synthesized in four steps from thymidine, and characterized by 1H NMR and NOE experiments. The J(HF) coupling constants support a conformation in solution that is predominantly 2'-endo (S). Although