121353-87-5Relevant academic research and scientific papers
3',3'-Difluoro-3'-deoxythymidine: Comparison of anti-HIV activity to 3'- fluoro-3'-deoxythymidine
Bergstrom,Mott,De Clercq,Balzarini,Swartling
, p. 3369 - 3372 (1992)
3',3'-Difluoro-3'-deoxythymidine (3) has been synthesized in four steps from thymidine, and characterized by 1H NMR and NOE experiments. The J(HF) coupling constants support a conformation in solution that is predominantly 2'-endo (S). Although
Synthesis, structure-activity relationships, and drug resistance of β-D-3′-fluoro-2′,3′-unsaturated nucleosides as anti-HIV agents
Zhou, Wen,Gumina, Giuseppe,Chong, Youhoon,Wang, Jianing,Schinazi, Raymond F.,Chu, Chung K.
, p. 3399 - 3408 (2007/10/03)
Our recent studies demonstrated that D- and L-2′-fluoro-2′ ,3′-unsaturated nucleosides (D- and L-2′-F-d4Ns) display moderate to potent antiviral activities against HIV-1 and HBV. As an extension of these findings, β-D-3′-fluoro-2′,3′-unsaturated nucleosid
