3',3'-Difluoro-3'-deoxythymidine: Comparison of anti-HIV activity to 3'- fluoro-3'-deoxythymidine

DOI: 10.1021/jm00096a011

Source and publish data:

Journal of Medicinal Chemistry p. 3369 - 3372 (1992)

Update date:2022-08-28

Topics:

Authors:

Bergstrom

Mott Mott

De Clercq

Balzarini

Swartling

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Article abstract of DOI:10.1021/jm00096a011

3',3'-Difluoro-3'-deoxythymidine (3) has been synthesized in four steps from thymidine, and characterized by ¹H NMR and NOE experiments. The J(HF) coupling constants support a conformation in solution that is predominantly 2'-endo (S). Although

Full text of DOI:10.1021/jm00096a011

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