1213779-03-3

Upstream product

• 158471-23-9 (S)-N-((furan-2-yl)(phenyl)methyl)-4-methylbenzenesulfonamide 
• 1620023-58-6 C₁₈H₁₇NO₄S 
• 70-55-3 toluene-4-sulfonamide 
• 13707-47-6 2-furaldehyde tosylimine 
• 98-01-1 furfural 

Downstream Products

• 1213779-04-4 (2S)-1-(4-Methylphenylsulfonyl)-2-phenylpiperidin-3-one 

Relevant academic research and scientific papers

Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs

An efficient synthetic route towards tosyl-protected (2S)-phenyl-3- piperidone, a common intermediate for many drugs, has been developed in 5 steps in 54% yield from biomass derived furfural. The synthetic utility of the piperidone core structure was demonstrated with the synthesis of a NK 1 receptor antagonist. This journal is the Partner Organisations 2014.

3-PIPERIDONE COMPOUNDS AND THEIR USE AS NEUROKININ-1 (NK1) RECEPTOR ANTAGONISTS

The invention relates to 3-piperidone compounds, and in particular, to (2S)-phenyl-3-piperidone and its synthesis method. Use of the thus-synthesized 3-piperidone compounds as potent neurokinin-1 (NK1) receptor antagonists is also provided.

Concise total asymmetric synthesis of (S)-2-phenylpiperidin-3-one

Starting from readily available dihydropyridinones, we have developed the first synthesis of (S)-2-phenylpiperidin-3-one. While the scaffold appears relatively common, even in its racemic form, this original product can be considered as a potential precur