1214-79-5 Usage
Uses
Used in Pharmaceutical Applications:
5-(N,N-DIMETHYL)-AMILORIDE HYDROCHLORIDE is used as a therapeutic agent for managing conditions related to ion transport dysregulation. Its ability to block the Na+/H+ antiport can help in treating various diseases associated with abnormal ion transport.
Used in Pain Management:
5-(N,N-DIMETHYL)-AMILORIDE HYDROCHLORIDE is used as an analgesic agent for reducing inflammatory pain. Its mechanism of action involves blocking the Na+/H+ antiport, which can help in alleviating pain caused by inflammation.
Used in Research:
5-(N,N-DIMETHYL)-AMILORIDE HYDROCHLORIDE is used as a research tool for studying the role of Na+/H+ antiport in various biological processes. It can be employed in experimental setups to investigate the effects of blocking this transporter on cell signaling, ion homeostasis, and other related phenomena.
Used in Drug Development:
5-(N,N-DIMETHYL)-AMILORIDE HYDROCHLORIDE serves as a lead compound in the development of new drugs targeting the Na+/H+ antiport. Its selective blocking activity can be exploited to design more potent and specific inhibitors for treating diseases related to ion transport dysregulation.
Used in Diagnostic Applications:
5-(N,N-DIMETHYL)-AMILORIDE HYDROCHLORIDE can be used as a diagnostic agent to assess the functionality of the Na+/H+ antiport in cells or tissues. By measuring the response to 5-(N,N-DIMETHYL)-AMILORIDE HYDROCHLORIDE, researchers and clinicians can gain insights into the role of this transporter in health and disease.
Biochem/physiol Actions
Selective blocker of Na+/H+ antiport; IC50 = 6.9 μM.
Check Digit Verification of cas no
The CAS Registry Mumber 1214-79-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,2,1 and 4 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1214-79:
(6*1)+(5*2)+(4*1)+(3*4)+(2*7)+(1*9)=55
55 % 10 = 5
So 1214-79-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H12ClN7O/c1-16(2)6-4(9)13-3(5(10)14-6)7(17)15-8(11)12/h1-2H3,(H2,10,14)(H4,11,12,15,17)
1214-79-5Relevant academic research and scientific papers
Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3)
Kuduk, Scott D.,Di Marco, Christina N.,Chang, Ronald K.,DiPardo, Robert M.,Cook, Sean P.,Cato, Matthew J.,Jovanovska, Aneta,Urban, Mark O.,Leitl, Michael,Spencer, Robert H.,Kane, Stefanie A.,Bilodeau, Mark T.,Hartman, George D.,Bock, Mark G.
scheme or table, p. 2514 - 2518 (2009/12/25)
A series of amiloride derivatives modified at the 5-position of the pyrazine ring were evaluated as inhibitors of acid-sensing ion channel-3 (ASIC3), a novel target for the treatment of chronic pain.
N-pyrazinecarbonyl-N'-acylguanidines
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, (2008/06/13)
The case involves novel N-pyrazinecarbonyl-N'-acylguanidines and processes for preparing same. The N-pyrazinecarbonyl-N'-acylguanidines are eukalemic agents possessing diuretic and natriuretic properties.
N-pyrazinecarbonyl-N'-substituted-sulfamoylguanidine and processes for preparing same
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, (2008/06/13)
The case involves novel N-pyrazinecarbonyl-N'-substituted-sulfamoylguanidine and processes for preparing same. The N-pyrazinecarbonyl-N'-substituted-sulfamoylguanidines are excellent eukalemic agents possessing diuretic and natriuretic properties.
