121401-76-1

Basic information

• Product Name: 7,2'',3'',6'',2''',3''',4''',6'''-octa-O-acetyl-2,3,4',5',6',7'-hexa-O-benzylvalidamycin E
• CAS NO: 121401-76-1
• Molecular Weight: 1536.69
• Mol File: 121401-76-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7,2'',3'',6'',2''',3''',4''',6'''-octa-O-acetyl-2,3,4',5',6',7'-hexa-O-benzylvalidamycin E(CAS DataBase Reference)
• NIST Chemistry Reference: 7,2'',3'',6'',2''',3''',4''',6'''-octa-O-acetyl-2,3,4',5',6',7'-hexa-O-benzylvalidamycin E(121401-76-1)
• EPA Substance Registry System: 7,2'',3'',6'',2''',3''',4''',6'''-octa-O-acetyl-2,3,4',5',6',7'-hexa-O-benzylvalidamycin E(121401-76-1)

Safety Data

• Hazardous Substances Data: 121401-76-1(Hazardous Substances Data)

Upstream product

• 86733-62-2 7-O-acetyl-2,3,4',5',6',7'-hexa-O-benzylvalidoxylamine A 
• 14227-66-8 acetobromocellobiose 
• 4753-07-5 2,3,6,2',3',4',6'-hepta-O-acetyl-lactosyl bromide 
• 4753-07-5 2,3,6,2',3',4',6'-hepta-O-acetyl-α-D-maltosyl bromide 

Downstream Products

• 12650-71-4 (+)-validamycin E 

Relevant articles and documents

Synthetic studies on antibiotic validamycins. Part 13. Total synthesis of (+)-validamycins A and E, and related compounds

(+)-Validoxylamine A (1) has been completely synthesized by deoxygenation of the validoxylamine B derivative (6) through formation of the aziridine, nucleophilic displacement with toluenethiol, reduction with Raney nickel, and deprotection. The validoxylamine A derivative (10) obtained was convertible, by glycosylation followed by deprotection, into validamycins A (2), E (3), and their analogues, which constitutes a total synthesis thereof.