121412-77-9

Basic information

• Product Name: CEFPROZIL (Z)-ISOMER (200 MG)H0E054927UG/MG(AI)
• Synonyms: CEFPROZIL (Z)-ISOMER (200 MG)H0E054927UG/MG(AI);Cefprozil (Z)-Isomer (200 mg);Cefprozil (Z)-IsoMer
• CAS NO: 121412-77-9
• Molecular Formula: C₁₈H₁₉N₃O₅S
• Molecular Weight: 389.42556
• Product Categories: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 121412-77-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 218-220° (dec)
• Boiling Point: 803.1±65.0 °C(Predicted)
• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• PKA: 2.92±0.50(Predicted)
• CAS DataBase Reference: CEFPROZIL (Z)-ISOMER (200 MG)H0E054927UG/MG(AI)(CAS DataBase Reference)
• NIST Chemistry Reference: CEFPROZIL (Z)-ISOMER (200 MG)H0E054927UG/MG(AI)(121412-77-9)
• EPA Substance Registry System: CEFPROZIL (Z)-ISOMER (200 MG)H0E054927UG/MG(AI)(121412-77-9)

Safety Data

• Hazardous Substances Data: 121412-77-9(Hazardous Substances Data)

Usage

Uses

Cefprozil (Z)-Isomer is a stereoisomer of Cefprozil (C243910), a semisynthetic oral cephalosporin consisting of approx. 90:10 Z/E isomeric mixture. Antibacterial.

Upstream product

• 106447-44-3 cis-7-amino-3-propen-1-yl-3-cephem-4-carboxylic acid 
• 37763-23-8 D-2-p-hydroxyphenylglycine methyl ester 
• 120709-09-3 (7R,8R)-7-amino-3-[propen-1-yl]-3-cephem-4-carboxylic acid 
• 78858-51-2 C₁₆H₁₉NO₇ 
• 685836-16-2 C₁₆H₂₈N₂O₃SSi₂ 

Relevant articles and documents

A refining method of Cefprozil (by machine translation)

The invention relates to a kind of Cefprozil refining method, including Cefprozil crude synthesis and Cefprozil refining, wherein the refining comprises: 1) will Cefprozil crude product in adding ethanol, stirring, dilute hydrochloric acid aqueous solution to adjust the pH to 2.0 - 2.2, stirring, dissolving crude product, filtering, to obtain the Cefprozil salt of the crude solution; 2) the above-mentioned solution adds by drops to 4% sodium bicarbonate solution, adjusting the pH to 4.6 - 5.0, cooling, thermal insulation mixing, filtering, washing, and a ground line, to get the solid; 3) step 2) the resulting solid dissolved in water, adding activated carbon, heating to 30 - 35 °C, fully stirring, after filtering the filtrate, the filtrate is cooled to 0 - 5 °C, added to the mixed solvent, crystallization, control the temperature and the stirring speed brilliantly 1.5 h, filtering, washing, and a ground line, vacuum drying, spore propylene pure product. The present invention provides a refined method has the simple conditions, cis-isomer content high, high purity and the like. (by machine translation)

Commercial synthesis of cefprozil: Development and control of process impurity

A process impurity, ethoxycarbonylcefprozil (9), formed in the synthesis of cefprozil (1) was controlled with addition of a catalytic amount of methanesulfonic acid.

PROCESSES FOR THE PREPARATION OF CEPHALOSPORIN DERIVATIVES

Provided is a process for preparing a compound of formula 1 or its salt. The process includes reacting a compound of formula 4 with acetaldehyde in a mixed solvent including water, isopropanol, and methylenechloride in a volume ratio of 1:3-6:11-14 in the