121425-22-7

Basic information

• Product Name: N,N-diethyl-3-chloro-2-<(trimethylsilyl)methyl>benzamide
• Synonyms: N,N-diethyl-3-chloro-2-<(trimethylsilyl)methyl>benzamide
• CAS NO: 121425-22-7
• Molecular Weight: 297.9
• Mol File: 121425-22-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N,N-diethyl-3-chloro-2-<(trimethylsilyl)methyl>benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-3-chloro-2-<(trimethylsilyl)methyl>benzamide(121425-22-7)
• EPA Substance Registry System: N,N-diethyl-3-chloro-2-<(trimethylsilyl)methyl>benzamide(121425-22-7)

Safety Data

• Hazardous Substances Data: 121425-22-7(Hazardous Substances Data)

Upstream product

• 15952-65-5 N,N-diethyl-m-chlorobenzamide 
• 75-77-4 chloro-trimethyl-silane 
• 121425-19-2 N,N-diethyl-3-chloro-2-methylbenzamide 

Downstream Products

• 121425-24-9 N,N-diethyl-3-chloro-2-(2'-hydroxy-2'-phenylethyl)benzamide 
• 1228658-13-6 3-chloro-2-((trimethylsilyl)methyl)benzaldehyde 

Relevant articles and documents

A practical in situ generation of the schwartz reagent. reduction of tertiary amides to aldehydes and hydrozirconation

A new, highly efficient in situ protocol (Cp2ZrCl2/LiAlH(OBu-t)3) is described for the generation of the Schwartz reagent which provides a convenient method for the amide to aldehyde reduction and the regioselective hydrozirconation-iodination of alkynes and alkenes. Highlighted are chemoselective reductions of benzamides derived by directed ortho metalation (DoM) chemistry, allowing the synthesis of valuable 1,2,3-substituted benzaldehydes. The single-step, three-component process proceeds in a very short reaction time, shows excellent functional group compatibility, and uses inexpensive and long-storage stable reducing reagents.