1214254-25-7

Basic information

• Product Name: 4-amino-1-ethylcyclohexan-1-ol
• Synonyms: 4-amino-1-ethylcyclohexan-1-ol
• CAS NO: 1214254-25-7
• Molecular Weight: 143.229
• Mol File: 1214254-25-7.mol

Chemical Properties

• CAS DataBase Reference: 4-amino-1-ethylcyclohexan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-1-ethylcyclohexan-1-ol(1214254-25-7)
• EPA Substance Registry System: 4-amino-1-ethylcyclohexan-1-ol(1214254-25-7)

Safety Data

• Hazardous Substances Data: 1214254-25-7(Hazardous Substances Data)

Upstream product

• 149506-81-0 trans-4-(dibenzylamino)cyclohexanol 
• 6850-65-3 p-hydroxycyclohexylamine 
• 149506-79-6 4-(dibenzylamino)cyclohexanone 
• 1214254-78-0 trans-4-(dibenzylamino)-1-ethylcyclohexanol 
• 331475-07-1 4-ethyl-4-hydroxycyclohexanone 
• 4746-97-8 cyclohexanedione monoethylene ketal 

Relevant articles and documents

Application of Transaminases in a Disperse System for the Bioamination of Hydrophobic Substrates

The challenging bioamination of hydrophobic substrates has been attained through the employment of a disperse system consisting of a combination of a low polarity solvent (e. g. isooctane or methyl-tert-butylether), a non-ionic surfactant and a minimal amount of water. In these conditions, amine transaminases (ATA) were shown to efficiently carry out the reductive amination of variously substituted cyclohexanones, providing good conversions often coupled with a superior stereoselectivity if compared with the corresponding chemical reductive amination. An array of synthetically useful 4-substituted aminocyclohexanes was consequentially synthesized through biocatalysis, analyzed and stereochemically characterized. (Figure presented.).

TRI-SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS

The present invention provides a tri-substituted pyrimidine compound having an excellent PDE10 inhibitory activity. The present invention relates to a tri-substituted pyrimidine compound represented by the following formula [I0] or a pharmaceutically acceptable salt thereof, a method for preparing the same, and use of said compound for PDE10 inhibitor, and a pharmaceutical composition comprising said compounds as an active ingredient: wherein: either one of X1 and X2 is N, and the other of X1 and X2 is CH; A is *-CH═CH—, *-C(Alk)=CH—, *-CH2—CH2— or *-O—CH2— (* is a bond with R1); Alk is a lower alkyl group; Ring B is an optionally substituted nitrogen-containing aliphatic heterocyclic group; R1 is an optionally substituted quinoxalinyl or an optionally substituted quinolyl; Y0 is mono- or di-substituted amino group, or a pharmaceutically acceptable salt thereof.