121445-54-3Relevant articles and documents
CONJUGATES OF WATER SOLUBLE POLYMER-AMINO ACID OLIGOPEPTIDE-DRUG, PREPARATION METHOD AND USE THEREOF
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Paragraph 0157; 0158, (2015/12/31)
A conjugate of water soluble polymer-amino acid oligopeptide-drug of Formula (I) below and a pharmaceutical composition comprising the conjugate are provided. In the conjugate, P is a water soluble polymer; X is a linking group, wherein the linking group links P and A1; each of A1, A2 and A3 is independently same or different amino acid residue or amino acid analogue residue; each of D1 and D2 is independently same or different drug molecule residue; a is 0 or 1; b is an integer of 2-12; c is an integer of 0-7; d is 0 or 1. The conjugate could improve drug load capacity, water solubility, stability and activity of the drug.
The β-Type Structures of Very Simple N-Octanoyl-L-glutamic Acid Oligomers (Residue Number, N = 2 - 6) and Their β1 -> β2 - Type Transition
Uehara, Toshiyuki,Okabayashi, Hirofumi,Taga, Keijiro,Yoshida, Tadayoshi,Kojima, Hiroshi,Nishio, Etuso
, p. 2196 - 2203 (2007/10/02)
N-Octanoyl-L-glutamic acid oligomers (residue number, N = 2 - 6) have been synthesized in order to study their molecular conformations in the solid state.The X-ray powder diffraction patterns and vibrational spectra of these oligomers have been investigat