121445-54-3

Upstream product

• 13574-13-5 Boc-Glu(OBzl)-OH 
• 82082-83-5 H-Glu(OBzl)-Glu(OBzl)-OBzl 
• 13574-84-0 dicyclohexylamine salt of γ-benzyl Boc-glutamate 
• 82082-82-4 H-Glu(OBzl)-Glu(OBzl)-OBzl*HCl 
• 2768-50-5 dibenzyl L-glutamate 
• 56-86-0 L-glutamic acid 
• 104-15-4 toluene-4-sulfonic acid 
• 2791-84-6 L-glutamic acid dibenzyl ester 4-toluenesulfonate 
• 100-51-6 benzyl alcohol 
• 89092-61-5 N-tertbutyloxycarbonyl dipeptide of benzyl glutamate 

Downstream Products

• 89107-70-0 Glu(OBzl)4-OBzl 
• 89107-69-7 Boc-Glu(OBzl)4-OBzl 
• 146552-80-9 (S)-2-((S)-4-Benzyloxycarbonyl-2-{(S)-4-benzyloxycarbonyl-2-[(S)-4-benzyloxycarbonyl-2-((S)-4-benzyloxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-butyrylamino]-butyrylamino}-butyrylamino)-pentanedioic acid dibenzyl ester 
• 146552-86-5 (S)-2-[(S)-4-Benzyloxycarbonyl-2-((S)-4-benzyloxycarbonyl-2-octanoylamino-butyrylamino)-butyrylamino]-pentanedioic acid dibenzyl ester 
• 146552-87-6 (S)-2-{(S)-4-Benzyloxycarbonyl-2-[(S)-4-benzyloxycarbonyl-2-((S)-4-benzyloxycarbonyl-2-octanoylamino-butyrylamino)-butyrylamino]-butyrylamino}-pentanedioic acid dibenzyl ester 
• 82095-14-5 HCl*Glu(OBzl)4-OBzl 

Relevant academic research and scientific papers

Synthesis and preliminary evaluation of novel bone-targeting NSAIDs prodrugs based on glutamic acid oligopeptides

Osteoarthritis is no doubt a difficult disease to manage. Targeted delivery of drugs to bone may not only enhance the treatment efficacy, but also reduces the quantity of drug administered. In this paper, we have synthesized two series of NSAID-Glu oligop

CONJUGATES OF WATER SOLUBLE POLYMER-AMINO ACID OLIGOPEPTIDE-DRUG, PREPARATION METHOD AND USE THEREOF

A conjugate of water soluble polymer-amino acid oligopeptide-drug of Formula (I) below and a pharmaceutical composition comprising the conjugate are provided. In the conjugate, P is a water soluble polymer; X is a linking group, wherein the linking group links P and A1; each of A1, A2 and A3 is independently same or different amino acid residue or amino acid analogue residue; each of D1 and D2 is independently same or different drug molecule residue; a is 0 or 1; b is an integer of 2-12; c is an integer of 0-7; d is 0 or 1. The conjugate could improve drug load capacity, water solubility, stability and activity of the drug.

The β-Type Structures of Very Simple N-Octanoyl-L-glutamic Acid Oligomers (Residue Number, N = 2 - 6) and Their β1 -> β2 - Type Transition

N-Octanoyl-L-glutamic acid oligomers (residue number, N = 2 - 6) have been synthesized in order to study their molecular conformations in the solid state.The X-ray powder diffraction patterns and vibrational spectra of these oligomers have been investigat

Photoinduced Electron Transfer on a Single α-Helical Polypeptide Chain

Electron transfer on an α-helical polypeptide carrying the sequence L-p-(dimethylamino)phenylalanine (dmaPhe)-L-alanine-L-1-pyrenylalanine (pyrAla) at the midpoint of an α-helical poly(γ-benzyl L-glutamate) chain was studied.Conformational energy calculation for the side-chain orientations predicted that only one type of orientation is allowed for both the dmaPhe and the pyrAla units.The center-to-center (edge-to-edge) distance between the two chromophores was estimated to be 13.2 (9.4) Angstroem.The fluorescence spectrum showed no exciplex emission in thepolypeptide, in contrast to the strong exciplex observed for a model tripeptide having the same dmaPhe-Ala-pyrAla sequence.The rate of electron transfer was calculated from the decay times of pyrenyl fluorescence of the polypeptide in trimethyl phosphate and in tetrahydrofuran solutions.The ket was on the order of 1E5 (s-1).The activation enthalpy was 1.4 kcal mol-1 in trimethyl phosphate and smaller than 1 kcal mol-1 in less polar solvents near room temperature.It was even smaller at lower temperatures.The activation entropy was less than -25 eu, suggesting a nonadiabatic electron transfer.In contrast to the slow electron transfer in the polypeptide, the rate constant for the model tripeptide was on the order of 1E7-1E8 (s-1) around room temperature, and the activation enthalpy was higher than that in the polypeptide case.