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2791-84-6

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2791-84-6 Usage

Description

L-Glutamic acid dibenzyl ester 4-toluenesulfonate is a chemical compound composed of L-glutamic acid, dibenzyl ester, and 4-toluenesulfonate. It is widely recognized for its role in organic chemistry as a reagent for the protection of carboxylic acids. L-Glutamic acid dibenzyl ester 4-toluenesulfonate serves as a versatile blocking group in the synthesis of peptides, ensuring stability and preventing unwanted side reactions. Its utility extends to the synthesis of pharmaceuticals and other organic compounds, making it an indispensable tool for chemists in the development of novel compounds and materials.

Uses

Used in Organic Chemistry:
L-Glutamic acid dibenzyl ester 4-toluenesulfonate is used as a protecting group for carboxylic acids during the synthesis of peptides. It provides stability to the carboxylic acid moiety and prevents unwanted reactions, ensuring the successful formation of the desired peptide sequence.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, L-Glutamic acid dibenzyl ester 4-toluenesulfonate is employed as a protecting group for carboxylic acids in the synthesis of various organic compounds. Its use facilitates the production of complex molecules with specific functional groups, contributing to the development of new drugs and therapeutic agents.
Used in Material Science:
L-Glutamic acid dibenzyl ester 4-toluenesulfonate also finds application in material science, where it is utilized in the synthesis of novel materials with unique properties. Its role as a protecting group for carboxylic acids allows for the controlled formation of complex structures, enabling the development of advanced materials for various applications.

Check Digit Verification of cas no

The CAS Registry Mumber 2791-84-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,7,9 and 1 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2791-84:
(6*2)+(5*7)+(4*9)+(3*1)+(2*8)+(1*4)=106
106 % 10 = 6
So 2791-84-6 is a valid CAS Registry Number.
InChI:InChI=1/C19H21NO4.C7H8O3S/c20-17(19(22)24-14-16-9-5-2-6-10-16)11-12-18(21)23-13-15-7-3-1-4-8-15;1-6-2-4-7(5-3-6)11(8,9)10/h1-10,17H,11-14,20H2;2-5H,1H3,(H,8,9,10)/t17-;/m0./s1

2791-84-6 Well-known Company Product Price

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  • Alfa Aesar

  • (H62697)  L-Glutamic acid dibenzyl ester p-toluenesulfonate, 98%   

  • 2791-84-6

  • 1g

  • 823.0CNY

  • Detail
  • Alfa Aesar

  • (H62697)  L-Glutamic acid dibenzyl ester p-toluenesulfonate, 98%   

  • 2791-84-6

  • 5g

  • 3696.0CNY

  • Detail
  • Alfa Aesar

  • (H62697)  L-Glutamic acid dibenzyl ester p-toluenesulfonate, 98%   

  • 2791-84-6

  • 25g

  • 8232.0CNY

  • Detail

2791-84-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name dibenzyl (2S)-2-aminopentanedioate,4-methylbenzenesulfonic acid

1.2 Other means of identification

Product number -
Other names L-glutamic acid dibenzyl ester p-tosylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:2791-84-6 SDS

2791-84-6Relevant articles and documents

p-Toluenesulfonyl Chloride Catalysed Facile Synthesis of O-benzyl-l-amino Acids and Their In Vitro Evaluation

Hegde, Namita,Juvale, Kapil,Prabhakar, Bala

, p. 2129 - 2135 (2020/01/11)

Protection and subsequent deprotection of amino acid functional groups play a key role in regioselective peptide synthesis. For protection, carboxylic acid functional groups are often benzylated using p-toluenesulfonic acid catalysed Fischer-Speier esterification reaction. Such reaction involves in situ water formation, which requires subsequent separation by azeotropic distillation for forward shift of equilibrium. To eliminate the need of this corresponding step requiring additional set-up, current study investigated p-toluenesulfonyl chloride as a reasonable alternative catalyst for facile benzylation of selected mono- and di- carboxylic amino acids. Literature reports that p-toluenesulfonyl chloride not only has a better shelf life but also demonstrates better safety in case of accidental systemic absorption over p-toluenesulfonic acid. As the O-benzyl-l-amino acids are often retained without deprotection to constitute the pharmaceutical peptide systems, synthesized compounds were investigated for their biocompatibility using in vitro cytotoxicity assays.

CONJUGATES OF WATER SOLUBLE POLYMER-AMINO ACID OLIGOPEPTIDE-DRUG, PREPARATION METHOD AND USE THEREOF

-

Paragraph 0134; 0135, (2015/12/31)

A conjugate of water soluble polymer-amino acid oligopeptide-drug of Formula (I) below and a pharmaceutical composition comprising the conjugate are provided. In the conjugate, P is a water soluble polymer; X is a linking group, wherein the linking group links P and A1; each of A1, A2 and A3 is independently same or different amino acid residue or amino acid analogue residue; each of D1 and D2 is independently same or different drug molecule residue; a is 0 or 1; b is an integer of 2-12; c is an integer of 0-7; d is 0 or 1. The conjugate could improve drug load capacity, water solubility, stability and activity of the drug.

Synthesis of NO-NSAID dendritic prodrugs via Passerini reaction:new approach to the design of dendrimer-drug conjugates

Du, Zuyin,Yanhui, Lu,Dai, Xuedong,Zhang-Negrerie, Daisy,Gao, Qingzhi

, p. 181 - 185 (2013/07/05)

We report the synthesis of a novel class of dendritic prodrugs via Passerini reaction in one pot. Such dendrimers feature a simultaneous attachment of a conventional non-steroidal anti-inflammatory drug (NSAID) (such as ibuprofen and aspirin) and a nitric oxide (NO)-releasing moiety (such as an organic nitrate) onto their surface, and are therefore regarded as new drug delivery systems for NO-releasing NSAIDs (NO-NSAIDs).

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