121497-16-3

Upstream product

• 14205-39-1 methyl 3-aminocrotonate 
• 16588-34-4 4-chloro-3-nitro-benzaldehyde 
• 51384-20-4 1,4-dihydro-2,6-dimethyl-4-(3-nitro-4-chlorophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester 
• 74-89-5 methylamine 

Downstream Products

• 121497-28-7 4-<4-(methylamino)-3-aminophenyl>-2,6-dimethyl-3,5-bis(methoxycarbonyl)-1,4-dihydropyridine 

Relevant academic research and scientific papers

Syntheses and bioevaluation of substituted dihydropyridines for pregnancy-interceptive activity in hamsters

A number of 2,6-dimethyl-3,5-bis(methoxycarbonyl)-4-substituted-1,4-dihydropyridines were synthesized and evaluated for pregnancy-interceptive activity in mated hamsters. Our of 24 compounds, 12, 15, 21, 22, 28, and 34 caused a marked reduction in the number of implantations when administered on days 3-8 postcoitum. In an in vitro competition assay, none of the compounds exhibited noticeable binding affinity for uterine progesterone receptors. The results reported here have helped to identify new leads for developing pregnancy-interceptive agents and the active compounds do not seem to elicit their interceptive effect through receptor-mediated inhibition of progesterone action in hamster uterus.