1215005-85-8Relevant academic research and scientific papers
Improved radiosynthesis of the apoptosis marker 18F-ICMT11 including biological evaluation
Glaser, Matthias,Goggi, Julian,Smith, Graham,Morrison, Matthew,Luthra, Sajinder K.,Robins, Edward,Aboagye, Eric O.
, p. 6945 - 6949 (2011)
We improved the specific radioactivity of the apoptosis imaging isatin derivative 18F-ICMT11. We then evaluated 18F-ICMT11 in EL4 tumor-bearing mice 24 h after treatment with etoposide/cyclophosphamide combination therapy. Dynamic PE
In vivo imaging used as isatin deriv.
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Paragraph 0130; 0228, (2016/11/17)
Isatin 5-sulfonamide derivatives, pharmaceutical compositions comprising the derivatives, their use as molecular imaging agents, their use for the diagnosis or treatment of diseases or disorders associated with dysregulation of apoptosis, methods for synthesizing the derivatives, methods for the molecular imaging of caspase activity and apoptosis, and methods of assessing the therapeutic effect of a test substance on caspase activity are disclosed.
