1215022-49-3Relevant academic research and scientific papers
Discovery of new SCH 39166 analogs as potent and selective dopamine D1 receptor antagonists
Qiang, Li,Sasikumar,Burnett, Duane A.,Su, Jing,Tang, Haiqun,Ye, Yuanzan,Mazzola Jr., Robert D.,Zhu, Zhaoning,McKittrick, Brian A.,Greenlee, William J.,Fawzi, Ahmad,Smith, Michelle,Zhang, Hongtao,Lachowicz, Jean E.
, p. 836 - 840 (2010)
A series of novel dopamine D1 antagonists derived from functionalization of the D-ring of SCH 39166 were prepared. A number of these compounds displayed subnanomolar D1 activity and more than 1000-fold selectivity over D2.
Selective D1/D5 receptor antagonists for the treatment of obesity and CNS disorders
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Page/Page column 23-24, (2008/06/13)
The present invention provides compounds, which, are novel antagonists for D1/D5 receptors as well as methods for preparing such compounds. In another embodiment, the invention provides pharmaceutical compositions comprising such Ds
