1215022-46-0Relevant academic research and scientific papers
Discovery of new SCH 39166 analogs as potent and selective dopamine D1 receptor antagonists
Qiang, Li,Sasikumar,Burnett, Duane A.,Su, Jing,Tang, Haiqun,Ye, Yuanzan,Mazzola Jr., Robert D.,Zhu, Zhaoning,McKittrick, Brian A.,Greenlee, William J.,Fawzi, Ahmad,Smith, Michelle,Zhang, Hongtao,Lachowicz, Jean E.
scheme or table, p. 836 - 840 (2010/07/13)
A series of novel dopamine D1 antagonists derived from functionalization of the D-ring of SCH 39166 were prepared. A number of these compounds displayed subnanomolar D1 activity and more than 1000-fold selectivity over D2.
