121505-96-2

Upstream product

• 4530-20-5 BOC-glycine 
• 1826-67-1 vinyl magnesium bromide 
• 121505-93-9 tert-butyl N-{[methoxy(methyl)carbamoyl]methyl}carbamate 

Downstream Products

• 1185841-74-0 C₂₈H₄₀N₄O₃ 
• 1185841-64-8 (2R)-allyl 5-(benzyloxycarbonylamino)-2-(10-(2,2-diphenylethyl)-2,2-dimethyl-4,11-dioxo-3,12-dioxa-5,10-diazapentadec-14-en-7-ylamino)pentanoate 
• 1241096-36-5 (3R,5S)-5-(N-Boc-aminomethyl)-3-(N,N'-Cbz₂-3-guanidinopropyl)-1-(2,2-diphenylethyl)-1,4-diazepan-2-one 
• 1185841-67-1 (3R,5R)-5-(N-Boc-aminomethyl)-3-(N-Cbz-3-aminopropyl)-1-(2,2-diphenylethyl)-1,4-diazepan-2-one 
• 1185841-66-0 (3R,5S)-5-(N-Boc-aminomethyl)-3-(N-Cbz-3-aminopropyl)-1-(2,2-diphenylethyl)-1,4-diazepan-2-one 
• 1185841-59-1 2,2-dimethyl-10-(2,2-diphenylethyl)-4,7,11-trioxo-3,12-dioxa-5,10-diazapentadec-14-ene 
• 1185653-21-7 tert-butyl 4-(2,2-diphenylethylamino)-2-oxobutylcarbamate 
• 402921-67-9 (4-{benzyl[2-(bis-pyridin-2-ylmethylamino)ethyl]amino}-2-oxobutyl)carbamic acid tert-butyl ester 
• 244228-14-6 C₃₃H₄₅N₃O₈ 
• 244228-13-5 C₂₅H₃₉N₃O₅ 
• 244228-12-4 C₂₅H₃₉N₃O₅ 
• 244228-10-2 C₂₄H₃₆N₂O₇ 

Relevant academic research and scientific papers

INHIBITORS OF VAP-1

Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

METHODS OF MODULATING THE ACTIVITY OF THE MC1 RECEPTOR AND TREATMENT OF CONDITIONS RELATED TO THIS RECEPTOR

The present invention provides compounds of Formula (I) that are useful for binding and/or modulating the biological activity of the melanocortin-1 receptor (MC1R). Compounds of this invention can be used to treat diseases and/or conditions in which modulation of MC1R is beneficial. Such diseases and/or conditions include, but are not limited to, hyperpigmentation (including melasma), hypopigmentation (including vitiligo), melanoma, basal cell carcinoma, squamous cell carcinoma, erythropoietic protoporphyria, polymorphous light eruption, solar urticaria, photosensitivity, sunburn, inflammatory diseases, aberrant fibroblast activity and pain.

PEPTIDE TURN MIMETICS

Peptide mimetics of structure X herein which (i) provide a wide range of sidechain functions at all sidechain positions, (ii) can be incorporated in a peptide sequence, (iii) can be readily synthesized and (iv) have a variety of conformations. There is also provided a novel process which can provide valuable intermediates in relation to production of peptide mimetics of structure X which intermediates have a high degree of chemo- and stereo-selectivity. Preferred mimetics include structures I, II, III, IV, V and VI.

METHODS OF MODULATING THE ACTIVITY OF THE MC1 RECEPTOR AND TREATMENT OF CONDITIONS RELATED TO THIS RECEPTOR

The present invention provides compounds of Formula (I) that are useful for binding and/or modulating the biological activity of the melanocortin-1 receptor (MC1R). Compounds of this invention can be used to treat diseases and/or conditions in which modulation of MC1R is beneficial. Such diseases and/or conditions include, but are not limited to, hyperpigmentation (including melasma), hypopigmentation (including vitiligo), melanoma, basal cell carcinoma, squamous cell carcinoma, erythropoietic protoporphyria, polymorphous light eruption, solar urticaria, photosensitivity, sunburn, inflammatory diseases, aberrant fibroblast activity and pain.

METHODS OF MODULATING THE ACTIVITY OF THE MC3 AND/OR MC4 RECEPTORS AND TREATMENT OF CONDITIONS RELATED TO THESE RECEPTORS

The present invention provides compounds of Formula (I) that are useful for modulating the biological activity of the melanocortin-3 receptor (MC3R) and / or the melanocortin-4 receptor (MC4R). Compounds of this invention can be used to treat diseases and/or conditions in which modulation of MC3R and / or MC4R is beneficial. Such diseases and/or conditions include, but are not limited to, obesity, eating disorders (such as cachexia, anorexia, weight gain, weight loss), metabolic syndrome, diabetes, sexual dysfunction (such as erectile dysfunction and female sexual dysfunction), anxiety, depression, inflammation, addiction and alcohol intake.

3-AMINOALKYL-1,4-DIAZEPAN-2-ONE MELANOCORTIN-5 RECEPTOR ANTAGONISTS

The present invention provides compounds of Formula (I) that are useful for modulating the biological activity of the melanocortin-5 receptor (MC5R). Compounds of this invention can be used to treat diseases and/or conditions in which downregulation of MC5R is beneficial. Such diseases and/or conditions include, but are not limited to, acne, seborrhea, seborrheic dermatitis, cancer, and inflammatory diseases.

Bimetallic reactivity. Preparations, properties and structures of complexes formed by unsymmetrical binucleating ligands bearing 4- and 6-coordinate sites supported by alkoxide bridges

Four binucleating ligands which potentially could provide bimetallic complexes bearing 5- and 6-coordinate sites have been prepared. These ligands, which have alkoxide bridging groups, can be regarded as more elaborate versions of binucleating ligands which have tridentate chelates on each side of the alkoxy bridge. Unlike these previous, less complex ligands, the present series of binucleating ligands have a strong tendency to form oligomers. This has been demonstrated with a series of crystal structures of copper(II) complexes of these ligands. It is probable that oligomers are formed because of the high flexibility of the present ligands. The work serves to illustrate the limits of binuclear ligand design and suggests that, with alkoxide ligand bridges, rigidity is necessary in order to obtain bimetallic complexes with extended multidentate binucleating ligands. One of the ligands gives a mixed valence Mn(II)-Mn(IV) complex after O2 oxidation of a di-Mn(II) precursor.

A NEW SYNTHESIS OF N-PROTECTED α-AMINOMETHYL KETONES FROM GLYCINE

N-Protected α-aminomethyl ketones can be prepared by reaction of glycine derivatives with various carbanions.