1215074-30-8 Usage
Description
5-bromo-2-(4-(trifluoromethyl)phenyl)pyridine is a pyridine derivative with the molecular formula C12H8BrF3N. It features a bromine atom at the 5th position and a trifluoromethylphenyl group at the 2nd position, which endows it with unique structural and reactivity characteristics. This chemical compound is widely recognized for its utility in organic synthesis and medicinal chemistry, serving as a key building block for the creation of pharmaceuticals and agrochemicals. The presence of the trifluoromethyl group also enhances the lipophilicity and metabolic stability of the molecules it is incorporated into, making it a valuable component in the development of new drugs and chemical processes.
Uses
Used in Organic Synthesis:
5-bromo-2-(4-(trifluoromethyl)phenyl)pyridine is used as a building block in organic synthesis for the creation of complex organic molecules. Its unique structure allows for versatile chemical reactions, facilitating the synthesis of a wide range of compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 5-bromo-2-(4-(trifluoromethyl)phenyl)pyridine is utilized as a key intermediate in the synthesis of pharmaceuticals. Its reactivity and the properties conferred by the trifluoromethyl group make it an essential component in the development of new drugs with improved pharmacokinetic and pharmacodynamic profiles.
Used in Agrochemical Development:
5-bromo-2-(4-(trifluoromethyl)phenyl)pyridine is also employed in the agrochemical industry as a precursor for the synthesis of various agrochemicals. Its role in this industry is crucial for the development of effective and stable pesticides and other agricultural chemicals.
Used in Drug Design for Enhanced Properties:
The trifluoromethyl group in 5-bromo-2-(4-(trifluoromethyl)phenyl)pyridine is used to improve the lipophilicity and metabolic stability of drug molecules. This modification can lead to better absorption, distribution, metabolism, and excretion (ADME) properties, which are critical for the drug's efficacy and safety.
Used in Chemical Process Development:
5-bromo-2-(4-(trifluoromethyl)phenyl)pyridine is utilized in the development of new chemical processes, where its reactivity and structural features can be leveraged to optimize reaction conditions and improve the yield and selectivity of desired products.
Check Digit Verification of cas no
The CAS Registry Mumber 1215074-30-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,5,0,7 and 4 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1215074-30:
(9*1)+(8*2)+(7*1)+(6*5)+(5*0)+(4*7)+(3*4)+(2*3)+(1*0)=108
108 % 10 = 8
So 1215074-30-8 is a valid CAS Registry Number.
1215074-30-8Relevant articles and documents
Orthogonal Nanoparticle Catalysis with Organogermanes
Fricke, Christoph,Sherborne, Grant J.,Funes-Ardoiz, Ignacio,Senol, Erdem,Guven, Sinem,Schoenebeck, Franziska
supporting information, p. 17788 - 17795 (2019/11/13)
Although nanoparticles are widely used as catalysts, little is known about their potential ability to trigger privileged transformations as compared to homogeneous molecular or bulk heterogeneous catalysts. We herein demonstrate (and rationalize) that nanoparticles display orthogonal reactivity to molecular catalysts in the cross-coupling of aryl halides with aryl germanes. While the aryl germanes are unreactive in LnPd0/LnPdII catalysis and allow selective functionalization of established coupling partners in their presence, they display superior reactivity under Pd nanoparticle conditions, outcompeting established coupling partners (such as ArBPin and ArBMIDA) and allowing air-tolerant, base-free, and orthogonal access to valuable and challenging biaryl motifs. As opposed to the notoriously unstable polyfluoroaryl- and 2-pyridylboronic acids, the corresponding germanes are highly stable and readily coupled. Our mechanistic and computational studies provide unambiguous support of nanoparticle catalysis and suggest that owing to the electron richness of aryl germanes, they preferentially react by electrophilic aromatic substitution, and in turn are preferentially activated by the more electrophilic nanoparticles.
Palladium-catalyzed highly regioselective 2-arylation of 2,x-dibromopyridines and its application in the efficient synthesis of a 17β-HSD1 inhibitor
Zhou, Qizhong,Zhang, Bin,Su, Liangjun,Jiang, Tiansheng,Chen, Rener,Du, Tieqi,Ye, Yuyuan,Shen, Jianfen,Dai, Guoliang,Han, Deman,Jiang, Huajiang
, p. 10996 - 11003 (2014/01/06)
2,3- and 2,5-Dibromopyridines reacted with arylboronic acids, catalyzed by Pd(OAc)2/PPh3 in the presence of K2CO 3 in CH3CN/MeOH (2:1) at 50 C for 24 h, to afford 2-arylpyridines in good to high yield
