1215082-94-2Relevant academic research and scientific papers
3-Halomethylated cyclic nitronates: Synthesis and nucleophilic substitution
Mikhaylov, Andrey A.,Dilman, Alexander D.,Struchkova, Marina I.,Khomutova, Yulia A.,Korlyukov, Alexander A.,Ioffe, Sema L.,Tartakovsky, Vladimir A.
, p. 4584 - 4594 (2011/07/08)
A method for the introduction of a halogen atom into the methyl group attached to the C-3 atom of five- and six-membered cyclic nitronates (isoxazoline N-oxides and oxazine N-oxides, respectively) has been studied. The process involves silylation of start
Synthesis and reactions of 3-halomethyl-substituted oxazine N-oxides
Mikhaylov, Andrey A.,Dilman, Alexander D.,Kunetsky, Roman A.,Khomutova, Yulia A.,Struchkova, Marina I.,Korlyukov, Alexander A.,Ioffe, Sema L.,Tartakovsky, Vladimir A.
supporting information; experimental part, p. 1038 - 1040 (2010/04/05)
A series of 3-halomethyl-5,6-dihydro-1,2-oxazine N-oxides (halogen = Cl, Br, I) is prepared from 4-phenyl-3,6,6-trimethyl-5,6-dihydro-4H-oxazine N-oxide by means of a silylation/halogenation sequence. The obtained halogenated N-oxides undergo reactions typical of cyclic six-membered nitronates including 1,3-dipolar cycloaddition, addition of nucleophiles, and substitution of the halogen by C-, S-, and N-nucleophiles.
