1215085-92-9 Usage
Description
GLPG0492 is a selective androgen receptor modulator (SARM). It activates the androgen receptor in a transactivation assay (EC50 = 12 nM in HeLa cells expressing the human receptor). GLPG0492 (10 mg/kg per day) increases levator ani muscle weight, a marker of anabolic activity, but has no effect on ventral prostate weight, a marker of androgenic activity, in castrated rats. It increases twitch tension in isolated diaphragm strips, as well as increases the total distance run in a treadmill test and decreases gastrocnemius muscle fibrosis in the exercised-mdx mouse model of muscular dystrophy when administered at a dose of 30 mg/kg. GLPG0492 also reverses immobilization-induced muscle atrophy in a mouse model of hindlimb immobilization.
Uses
GLPG-0492 is a non-steroidal Selective Androgen Receptor Modulator (SARM), which can be used to reduce muscle loss while sparing reproductive tissues.
Check Digit Verification of cas no
The CAS Registry Mumber 1215085-92-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,5,0,8 and 5 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1215085-92:
(9*1)+(8*2)+(7*1)+(6*5)+(5*0)+(4*8)+(3*5)+(2*9)+(1*2)=129
129 % 10 = 9
So 1215085-92-9 is a valid CAS Registry Number.
1215085-92-9Relevant articles and documents
Identification of a 4-(hydroxymethyl)diarylhydantoin as a selective androgen receptor modulator
Nique, Francois,Hebbe, Severine,Triballeau, Nicolas,Peixoto, Christophe,Lefrancois, Jean-Michel,Jary, Helene,Alvey, Luke,Manioc, Murielle,Housseman, Christopher,Klaassen, Hugo,Van Beeck, Kris,Guedin, Denis,Namour, Florence,Minet, Dominque,Van Der Aar, Ellen,Feyen, Jean,Fletcher, Stephen,Blanque, Roland,Robin-Jagerschmidt, Catherine,Deprez, Pierre
, p. 8236 - 8247,12 (2020/09/15)
Structural modification performed on a 4-methyl-4-(4-hydroxyphenyl) hydantoin series is described which resulted in the development of a new series of 4-(hydroxymethyl)diarylhydantoin analogues as potent, partial agonists of the human androgen receptor. T
