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4-aMino-3-Pyrrolidinol hydrochloride is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1215210-04-0

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1215210-04-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1215210-04-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,5,2,1 and 0 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1215210-04:
(9*1)+(8*2)+(7*1)+(6*5)+(5*2)+(4*1)+(3*0)+(2*0)+(1*4)=80
80 % 10 = 0
So 1215210-04-0 is a valid CAS Registry Number.

1215210-04-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-aminopyrrolidin-3-ol,dihydrochloride

1.2 Other means of identification

Product number -
Other names 4-Aminopyrrolidin-3-ol dihydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1215210-04-0 SDS

1215210-04-0Downstream Products

1215210-04-0Relevant articles and documents

Deoxyiminoalditols from aldonic acids VI. Preparation of the four stereoisomeric 4-amino-3-hydroxypyrrolidines from bromodeoxytetronic acids. Discovery of a new α-mannosidase inhibitor

Limberg, Gerrit,Lundt, Inge,Zavilla, John

, p. 178 - 183 (1999)

A convenient four step synthesis of 4-amino-3-hydroxypyrrolidines is presented. From the readily available D- and L-tetronic acids the four possible stereoisomeric 4-amino-3-hydroxypyrrolidines 14 (3R,4R), 15 (3R,4S), ent-14 (3S,4S) and ent-15 (3S,4R) could be obtained as crystalline compounds, avoiding any chromatographic purification. The key step in the reactions was the regioselective formation of either the 2,4-diamino-2,4-di-deoxy-D- threono-D-1,4-lactam (5) or the 3,4-diamino-3,4-dideoxy-L-erythrono-1,4- lactam (10) by treatment of the methyl 4-bromo-4-deoxy-2,3-cis- or -2,3- trans-anhydrotetronates (3 or 9), respectively, with liquid ammonia. Thus, opposite regioselectivity for the opening of the c/s-configurated epoxide 3 (4:1, C-2/c-3) and the trans-configurated epoxide 9 (3:7, C-2/c-3) by ammonia was observed. Preliminary testing as glycosidase inhibitors of the 4-amino- 3-hydroxypyrrolidines formed by reduction of the lactams showed an inhibition of α-mannosidase (K1 40 μM) by isomer 14, (3R,4R)-4-amino-3- hydroxypyrrolidine.

BENZAMIDE DERIVATIVES FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1

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Paragraph 00706-00707, (2013/12/03)

The present invention relates to compounds of formula (I): in which Y, Y, R, R 2, R 3 and R 4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.

Chemoenzymatic synthesis of orthogonally protected (3R,4R)- and (3S,4S)-trans-3-amino-4-hydroxypyrrolidines

Rodríguez-Rodríguez, Jesús A.,Quijada, F. Javier,Brieva, Rosario,Rebolledo, Francisca,Gotor, Vicente

, p. 5407 - 5412 (2013/07/05)

Several orthogonally protected racemic trans-3-amino-4-hydroxypyrrolidines have been easily prepared from N-Cbz-3,4-epoxypyrrolidine. Resolution of each racemic compound was accomplished by means of lipase-catalyzed aminolysis, transesterification or hydr

IMPROVED AMINOHYDROXYLATION OF ALKENES

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Page/Page column 54-55, (2012/01/06)

The invention relates to a process for the aminohydroxylation of alkenes using N-oxycarbamate reagents, e.g. N-acyloxycarbamate, N-alkyloxycarbonyloxycarbamate and N-aralkoxycarbonyloxycarbamate reagents. The invention particularly relates to an intermolecular aminohydroxylation reaction that can be carried out in the absence of added base. The invention also relates to novel N-oxycarbamate reagents that are stable crystalline materials. The process of the invention is useful in the synthesis of compounds having a vicinal amino alcohol moiety, such as biologically active compounds.

Alkyl 4-chlorobenzoyloxycarbamates as highly effective nitrogen source reagents for the base-free, intermolecular aminohydroxylation reaction

Harris, Lawrence,Mee, Simon P. H.,Furneaux, Richard H.,Gainsford, Graeme J.,Luxenburger, Andreas

experimental part, p. 358 - 372 (2011/04/17)

Ethyl-(7), benzyl-(8), tert-butyl-(9), and fluorenylmethyl-4- chlorobenzoyloxycarbamates (10) have been prepared as storable and easy-to-prepare nitrogen sources for use in the intermolecular Sharpless aminohydroxylation reaction and its asymmetric variant. These reagents were found to be effective under base-free reaction conditions. The scope and limitations of these methods have been explored using a variety of alkenes, among which, trans-cinnamates, in particular, proved to be good substrates.

THIENO-PYRIDINE DERIVATIVES AS MEK INHIBITORS

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Page/Page column 44, (2010/01/12)

A series of thieno[2,3-6]pyridine derivatives, attached at the 2-position to a substituted anilino moiety, which are substituted in the 3-position by a carbonyl group linked to a pyrrolidin-1-yl ring which in turn forms part of a heteroatom-containing fus

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