708273-49-8Relevant academic research and scientific papers
Chemoenzymatic synthesis of orthogonally protected (3R,4R)- and (3S,4S)-trans-3-amino-4-hydroxypyrrolidines
Rodríguez-Rodríguez, Jesús A.,Quijada, F. Javier,Brieva, Rosario,Rebolledo, Francisca,Gotor, Vicente
, p. 5407 - 5412 (2013/07/05)
Several orthogonally protected racemic trans-3-amino-4-hydroxypyrrolidines have been easily prepared from N-Cbz-3,4-epoxypyrrolidine. Resolution of each racemic compound was accomplished by means of lipase-catalyzed aminolysis, transesterification or hydr
MODULATORS OF CELLULAR ADHESION
-
Page/Page column 126-127, (2010/02/11)
The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).
Substituted aryl 1,4-pyrazine derivatives
-
, (2008/06/13)
Substituted aryl 1,4-pyrazine derivatives and their use in treating anxiety disorders, depression and stress related disorders are disclosed.
